Centre for Research in Evidence-Based practice - Bond University & The University of Sydney
Influenza vaccine
Main Editor
Pinika Patel
Language
en
Last Update
Jul 22, 2019
Published Date
Jul 22, 2019
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Abstract
PICOS
PICO 1.1
P: Healthy individuals aged 16 to 65 years, irrespective of influenza status in community-based studies in North America, South America, and Europe (1969 to 2009). Studies which had more than 25% of individuals outside the age range were excluded. Pregnant women were included together with their newborns. 52 clinical trials in over 80,000 people. Note 15 trials were industry funded (29%).
I: Inactivated parenteral influenza vaccine
C: placebo or 'do nothing'
O:
P: Healthy individuals aged 16 to 65 years, irrespective of influenza status in community-based studies in North America, South America, and Europe (1969 to 2009). Studies which had more than 25% of individuals outside the age range were excluded. Pregnant women were included together with their newborns. 52 clinical trials in over 80,000 people. Note 15 trials were industry funded (29%).
I: Inactivated parenteral influenza vaccine
C: placebo or 'do nothing'
O:
PICO 2.1
P: Vaccines for preventing influenza in healthy children - Healthy children under 16 years of age in any geographical location. All participants were classified as healthy unless otherwise stated.. Studies that documented the inclusion of participants with chronic illnesses/conditions or immunodeficiency were excluded
I: Influenza vaccine - All vaccine types
C: placebo
O:
P: Vaccines for preventing influenza in healthy children - Healthy children under 16 years of age in any geographical location. All participants were classified as healthy unless otherwise stated.. Studies that documented the inclusion of participants with chronic illnesses/conditions or immunodeficiency were excluded
I: Influenza vaccine - All vaccine types
C: placebo
O:
PICO 3.1
P: Elderly (people aged over 65) in community and residential care institutions in the USA and Europe during influenza seasons between 1965 and 2000 - Excluded studies assessing efficacy in selected groups affected by a specific chronic pathology (i.e. diabetes or cardiac disease), as we were interested in the whole population.
I: Influenza vaccines
C: no vaccination: cohort studies in nursing homes
O:
P: Elderly (people aged over 65) in community and residential care institutions in the USA and Europe during influenza seasons between 1965 and 2000 - Excluded studies assessing efficacy in selected groups affected by a specific chronic pathology (i.e. diabetes or cardiac disease), as we were interested in the whole population.
I: Influenza vaccines
C: no vaccination: cohort studies in nursing homes
O:
PICO 4.1
P: People with chronic obstructive pulmonary disease (COPD) - Included studies of adults with COPD, as defined by the American Thoracic Society (ATS 1995), or European Respiratory Society (Siafakas 1995). Also included studies with participants who were defined as having chronic bronchitis.
I: Inactivated influenza vaccine
C: Placebo
O:
P: People with chronic obstructive pulmonary disease (COPD) - Included studies of adults with COPD, as defined by the American Thoracic Society (ATS 1995), or European Respiratory Society (Siafakas 1995). Also included studies with participants who were defined as having chronic bronchitis.
I: Inactivated influenza vaccine
C: Placebo
O:
PICO 5.1
P: Influenza vaccines in immunosuppressed adults with cancer
I: Influenza vaccine
C: none
O:
P: Influenza vaccines in immunosuppressed adults with cancer
I: Influenza vaccine
C: none
O:
PICO 6.1
P: Pregnant women
I: Inactivated influenza vaccine
C: No vaccine
O:
P: Pregnant women
I: Inactivated influenza vaccine
C: No vaccine
O:
PICO 7.1
P: Children and Adults with Cystic Fibrosis
I: Intranasal live vaccine
C: Intramuscular trivalent inactivated vaccine
O:
P: Children and Adults with Cystic Fibrosis
I: Intranasal live vaccine
C: Intramuscular trivalent inactivated vaccine
O:
PICO 8.1
P: Vaccines for preventing influenza in children. Children under 16 years of age from any geographical location
I: inactivated influenza vaccination
C: placebo or do nothing
O:
P: Vaccines for preventing influenza in children. Children under 16 years of age from any geographical location
I: inactivated influenza vaccination
C: placebo or do nothing
O:
