Published by Zhikang Ye and Reed Siemieniuk on Jan 6, 2020
        
            
            
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Abstract
            BMJ Rapid Recommendation
        
        
            
Language
            en
        
     
    
        PICOS
            PICO 10.1
            
                
Population
                Critically ill patients at risk of GI bleeding
                
                
            
            
                
Intervention
                Proton pump inhibitor
                
                
            
            
                
Comparator
                No prophylaxis
                
                
            
            
                
Outcomes
                
                
               
            
            PICO 10.2
            
                
Population
                Critically ill patients at risk of GI bleeding
                
                
            
            
                
Intervention
                Histamine-2 receptor antagonist
                
                
            
            
                
Comparator
                No prophylaxis
                
                
            
            
                
Outcomes
                
                
               
            
            PICO 10.3
            
                
Population
                Critically ill patients at risk of GI bleeding
                
                
            
            
                
Intervention
                Sucralfate
                
                
            
            
                
Comparator
                No prophylaxis
                
                
            
            
                
Outcomes
                
                
               
            
            PICO 10.4
            
                
Population
                Critically ill patients at risk of GI bleeding
                
                
            
            
                
Intervention
                Proton pump inhibitor
                
                
            
            
                
Comparator
                Histamine-2 receptor antagonist
                
                
            
            
                
Outcomes
                
                
               
            
            PICO 10.5
            
                
Population
                Critically ill patients at risk of GI bleeding
                
                
            
            
                
Intervention
                Proton pump inhibitor
                
                
            
            
                
Comparator
                Sucralfate
                
                
            
            
                
Outcomes
                
                
               
            
            PICO 10.6
            
                
Population
                Critically ill patients at risk of GI bleeding
                
                
            
            
                
Intervention
                Histamine-2 receptor antagonist
                
                
            
            
                
Comparator
                Sucralfate
                
                
            
            
                
Outcomes