Clinical Practice Guideline for Solid Organ Donation and Transplantation During the COVID-19 Pandemic

Published by Lindsay Wilson on Sep 8, 2021

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Abstract

Language

en

PICOS

PICO 2.1

Population
Adult kidney transplant recipients with known or suspected COVID-19
Intervention
Adjustment to maintenance immunosuppression therapy
Comparator
Routine care (no adjustment to maintenance immunosuppression therapy)
Outcomes

PICO 2.2

Population
Paediatric kidney transplant recipients at risk for COVID-19
Intervention
Adjustment to maintenance immunosuppression therapy
Comparator
Routine care (no adjustment to maintenance immunosuppression therapy)
Outcomes

PICO 2.3

Population
Adult liver transplant recipients with known or suspected COVID-19
Intervention
Adjustment to maintenance immunosuppression therapy
Comparator
Routine care (no adjustment to maintenance immunosuppression therapy)
Outcomes

PICO 2.4

Population
Adult heart transplant recipients with known or suspected COVID-19
Intervention
Adjustment to maintenance immunosuppression therapy
Comparator
Routine care (no adjustment to maintenance immunosuppression therapy)
Outcomes

PICO 2.5

Population
Adult lung transplant recipients with known or suspected COVID-19
Intervention
Adjustment to maintenance immunosuppression therapy
Comparator
Routine care (no adjustment to maintenance immunosuppression therapy)
Outcomes

PICO 2.6

Population
Adult pancreas transplant recipients with known or suspected COVID-19
Intervention
Adjustment to maintenance immunosuppression therapy
Comparator
Routine care (no adjustment to maintenance immunosuppression therapy)
Outcomes

PICO 3.1

Population
Adult kidney transplant recipients who have acquired COVID-19
Intervention
Anti-COVID-19 therapy
Comparator
Routine care (no specific anti-COVID-19 therapy)
Outcomes

PICO 3.2

Population
Adult liver transplant recipients who have acquired COVID-19
Intervention
Anti-COVID-19 therapy
Comparator
Routine care (no specific anti-COVID-19 therapy)
Outcomes

PICO 3.3

Population
Adult heart transplant recipients who have acquired COVID-19
Intervention
Anti-COVID-19 therapy
Comparator
Routine care (no specific anti-COVID-19 therapy)
Outcomes

PICO 3.4

Population
Adult lung transplant recipients who have acquired COVID-19
Intervention
Anti-COVID-19 therapy
Comparator
Routine care (no specific anti-COVID-19 therapy)
Outcomes

PICO 4.1

Population
Adult kidney transplant recipients in settings of COVID-19 transmission
Intervention
Adjustment to induction immunosuppression
Comparator
Routine care (no adjustment to induction immunosuppression)
Outcomes

PICO 4.2

Population
Adult liver transplant recipients in settings of COVID-19 transmission
Intervention
Adjustment to induction immunosuppression
Comparator
Routine care (no adjustment to induction immunosuppression)
Outcomes

PICO 4.3

Population
Adult heart transplant recipients in settings of COVID-19 transmission
Intervention
Adjustment to induction immunosuppression
Comparator
Routine care (no adjustment to induction immunosuppression)
Outcomes

PICO 4.4

Population
Adult pancreas transplant recipients in settings of COVID-19 transmission
Intervention
Adjustment to induction immunosuppression
Comparator
Routine care (no adjustment to induction immunosuppression)
Outcomes

PICO 4.5

Population
Adult lung transplant recipients in settings of COVID-19 transmission
Intervention
Adjustment to induction immunosuppression
Comparator
Routine care (no adjustment to induction immunosuppression)
Outcomes

PICO 4.6

Population
Adult kidney transplant recipients in settings of COVID-19 transmission
Intervention
Adjustment to rejection treatment
Comparator
Routine care (no adjustment to rejection treatment)
Outcomes

PICO 4.7

Population
Adult liver transplant recipients in settings of COVID-19 transmission
Intervention
Adjustment to rejection treatment
Comparator
Routine care (no adjustment to rejection treatment)
Outcomes

PICO 4.8

Population
Adult heart transplant recipients in settings of COVID-19 transmission
Intervention
Adjustment to rejection treatment
Comparator
Routine care (no adjustment to rejection treatment)
Outcomes

PICO 4.9

Population
Adult pancreas transplant recipients in settings of COVID-19 transmission
Intervention
Adjustment to rejection treatment
Comparator
Routine care (no adjustment to rejection treatment)
Outcomes

PICO 4.10

Population
Adult lung transplant recipients in settings of COVID-19 transmission
Intervention
Adjustment to rejection treatment
Comparator
Routine care (no adjustment to rejection treatment)
Outcomes

PICO 6.1

Population
Adult kidney transplant candidates in areas with COVID 19
Intervention
Transplant
Comparator
Remain on dialysis/waitlist
Outcomes

PICO 6.2

Population
Adult kidney transplant candidates with COVID-19
Intervention
Transplant
Comparator
Remain on dialysis/waitlist
Outcomes

PICO 6.3

Population
Adult kidney transplant candidates in areas with COVID 19
Intervention
Transplant
Comparator
Remain on dialysis/waitlist
Outcomes

PICO 6.4

Population
Pediatric kidney transplant candidates in area with COVID 19
Intervention
Transplant
Comparator
Remain on dialysis/waitlist
Outcomes

PICO 6.5

Population
Adult liver transplant candidates in areas with COVID-19
Intervention
Transplantation
Comparator
Remain on organ replacement therapy/waitlist
Outcomes

PICO 6.6

Population
Adult heart transplant candidates in areas with COVID 19
Intervention
Transplantation
Comparator
Remain on organ replacement/waitlist
Outcomes

PICO 6.7

Population
Pediatric heart transplant candidates in areas with COVID 19
Intervention
Transplant
Comparator
Remain on organ replacement/waitlist
Outcomes

PICO 6.8

Population
Adult pancreas transplant candidates in areas with COVID 19
Intervention
Transplant
Comparator
Remain on organ replacement/waitlist
Outcomes

PICO 6.9

Population
Adult lung transplant candidates in areas with COVID 19
Intervention
Transplant
Comparator
Remain on organ replacement/waitlist
Outcomes

PICO 7.1

Population
Adult and pediatric solid organ transplant recipients
Intervention
Transplanting organs from COVID-19 positive donors
Comparator
Transplanting organs from COVID-19 negative donors
Outcomes

PICO 8.1

Population
Adult and pediatric deceased organ donors
Intervention
Screening for COVID-19 using RT-PCR
Comparator
Not Screening for COVID-19
Outcomes

PICO 8.2

Population
Adult and pediatric deceased organ donors
Intervention
Repeat PCR testing for COVID-19
Comparator
No repeat PCR testing for COVID-19
Outcomes

PICO 8.3

Population
Adult and pediatric deceased organ donors
Intervention
COVID-19 screening from the lower respiratory tract
Comparator
COVID-19 screening from the upper respiratory tract
Outcomes

PICO 9.1

Population
Adult and pediatric deceased organ donors
Intervention
Addition of chest CT to screen for COVID-19
Comparator
PCR testing alone
Outcomes

PICO 10.1

Population
Adult and pediatric deceased organ donors
Intervention
SARS-CoV-2 antibody testing for COVID
Comparator
RT-PCR testing for COVID
Outcomes