PICOS
PICO 10.1
Population
Adults with anterior circulation large vessel occlusion-related acute ischaemic stroke within 6 h after symptom onset
Intervention
Mechanical thrombectomy plus best medical management
Comparator
Best medical management alone
Outcomes
PICO 20.1
Population
Adults with anterior circulation large vessel occlusion-related acute ischaemic stroke 6 and 24 h from time last known well
Intervention
Mechanical thrombectomy plus best medical management
Comparator
Best medical management alone
Outcomes
PICO 30.1
Population
Adults with large vessel occlusion-related acute ischaemic stroke
Intervention
Intravenous thrombolysis plus mechanical thrombectomy
Comparator
Mechanical thrombectomy alone
Outcomes
PICO 60.1
Population
Patients aged 80 years or more with large vessel occlusion-related acute ischaemic stroke within 6 h of symptom onset
Intervention
Mechanical thrombectomy plus best medical management
Comparator
Best medical management alone
Outcomes
PICO 60.2
Population
Patients aged 80 years or more with large vessel occlusion-related acute ischaemic stroke between 6 and 24 h from time last known well
Intervention
Mechanical thrombectomy plus best medical management
Comparator
Best medical management
Outcomes
PICO 100.1
Population
Patients with large vessel occlusion-related acute ischaemic stroke
Intervention
Reperfusion TICI Grade 3
Comparator
Reperfusion TICI Grade 2b
Outcomes
PICO 130.1
Population
Adults with large vessel occlusion-related acute ischaemic stroke undergoing mechanical thrombectomy
Intervention
Conscious sedation
Comparator
General anaesthesia
Outcomes