PICOS
PICO 10.1
Population
Adults with type 2 diabetes plus 3 or fewer risk factors and no underlying CVD or CKD
Intervention
Sodium-Glucose Transport Protein 2 (SGLT2) inhibitors
Comparator
Standard care
Outcomes
PICO 10.2
Population
Adults with type 2 diabetes plus 3 or fewer risk factors and no underlying CVD or CKD
Intervention
Glucagon-Like Peptide-1 (GLP-1) receptor agonists
Comparator
Standard care
Outcomes
PICO 20.1
Population
Adults with type 2 diabetes plus 3 more risk factors and no underlying CVD or CKD
Intervention
Sodium-Glucose Transport Protein 2 (SGLT2) inhibitors
Comparator
Standard care
Outcomes
PICO 20.2
Population
Adults with type 2 diabetes plus 3 more risk factors and no underlying CVD or CKD
Intervention
Glucagon-Like Peptide-1 (GLP-1) receptor agonists
Comparator
Standard care
Outcomes
PICO 30.1
Population
Adults with type 2 diabetes and established CVD (but no CKD)
Intervention
Sodium-Glucose Transport Protein 2 (SGLT2) inhibitors
Comparator
Standard care
Outcomes
PICO 30.2
Population
Adults with type 2 diabetes and established CVD (but no CKD)
Intervention
Glucagon-Like Peptide-1 (GLP-1) receptor agonists
Comparator
Standard care
Outcomes
PICO 40.1
Population
Adults with type 2 diabetes and chronic kidney disease (but no CVD)
Intervention
Sodium-Glucose Transport Protein 2 (SGLT2) inhibitors
Comparator
Standard care
Outcomes
PICO 40.2
Population
Adults with type 2 diabetes and chronic kidney disease (but no CVD)
Intervention
Glucagon-Like Peptide-1 (GLP-1) receptor agonists
Comparator
Standard care
Outcomes
PICO 50.1
Population
Adults with type 2 diabetes and CVD and CKD
Intervention
Sodium-Glucose Transport Protein 2 (SGLT2) inhibitors
Comparator
Standard care
Outcomes
PICO 50.2
Population
Adults with type 2 diabetes and CVD and CKD
Intervention
Glucagon-Like Peptide-1 (GLP-1) receptor agonists
Comparator
Standard care
Outcomes
PICO 60.1
Population
Adults with type 2 diabetes with 3 or fewer risk factors and no underlying CVD or CKD
Intervention
Sodium-Glucose Transport Protein 2 (SGLT2) inhibitors
Comparator
Glucagon-Like Peptide-1 (GLP-1) receptor agonists
Outcomes
PICO 60.2
Population
Adults with type 2 diabetes with 3 or more risk factors and no underlying CVD or CKD
Intervention
Sodium-Glucose Transport Protein 2 (SGLT2) inhibitors
Comparator
Glucagon-Like Peptide-1 (GLP-1) receptor agonists
Outcomes
PICO 60.3
Population
Adults with type 2 diabetes with established CVD (but no CKD)
Intervention
Sodium-Glucose Transport Protein 2 (SGLT2) inhibitors
Comparator
Glucagon-Like Peptide-1 (GLP-1) receptor agonists
Outcomes
PICO 60.4
Population
Adults with type 2 diabetes and chronic kidney disease (but no CVD)
Intervention
Sodium-Glucose Transport Protein 2 (SGLT2) inhibitors
Comparator
Glucagon-Like Peptide-1 (GLP-1) receptor agonists
Outcomes
PICO 60.5
Population
Adults with type 2 diabetes and CVD and CKD
Intervention
Sodium-Glucose Transport Protein 2 (SGLT2) inhibitors
Comparator
Glucagon-Like Peptide-1 (GLP-1) receptor agonists
Outcomes