European Stroke Organisation (ESO) guidelines on intravenous thrombolysis for acute ischaemic stroke

Published by ESO on May 11, 2021

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Abstract

Language

en

PICOS

PICO 1.1

Population
Patients with acute ischaemic stroke of <4.5 h duration
Intervention
Intravenous thrombolysis with alteplase
Comparator
No intravenous thrombolysis
Outcomes

PICO 4.1

Population
Ppatients with acute ischaemic stroke on awakening from sleep/unknown onset
Intervention
Intravenous thrombolysis with alteplase
Comparator
No intravenous thrombolysis
Outcomes

PICO 5.1

Population
'Unselected' patients with acute ischaemic stroke of<4.5 h duration
Intervention
IVT with tenecteplase 0.25mg/kg
Comparator
IVT with alteplase 0.9 mg/kg
Outcomes

PICO 5.2

Population
'Unselected' patients with acute ischaemic stroke of<4.5 h duration
Intervention
IVT with tenecteplase 0.40mg/kg
Comparator
IVT with alteplase 0.9 mg/kg
Outcomes

PICO 5.3

Population
Patients with acute ischaemic stroke of<4.5 h duration and with large vessel occlusion, who are candidates for mechanical thrombectomy, and for whom intravenous thrombolysis is considered before thrombectomy
Intervention
IVT with tenecteplase
Comparator
IVT with alteplase
Outcomes

PICO 7.1

Population
Patients with acute ischaemic stroke of<4.5 h duration
Intervention
Ultrasound augmentation of IVT
Comparator
IVT alone
Outcomes

PICO 9.1

Population
Patients with acute minor, disabling ischaemic stroke of<4.5 h duration
Intervention
IVT with alteplase
Comparator
no IVT
Outcomes

PICO 10.1

Population
Patients with clinically severe acute ischaemic stroke of<4.5 h duration
Intervention
IVT with alteplase
Comparator
No IVT
Outcomes

PICO 10.2

Population
Extensive ischaemic change on baseline imaging
Intervention
IVT with alteplase
Comparator
No IVT
Outcomes

PICO 12.1

Population
Patients with acute ischaemic stroke of<4.5 h duration who use vitamin K antagonists
Intervention
IVT with alteplase
Comparator
No IVT
Outcomes

PICO 13.1

Population
Patients with acute ischaemic stroke of<4.5 h duration, who have cerebral white matter lesions
Intervention
IVT with alteplase
Comparator
No IVT
Outcomes