PICOS
PICO 10.1
Population
For adults with ICH
Intervention
management on an acute strokeunit
Comparator
care on a general ward
Outcomes
PICO 20.1
Population
For adults with acute ICH
Intervention
altering blood pressure to a particular target or with a specific agent
Comparator
an alternative target or agent
Outcomes
PICO 30.1
Population
For adults with acute ICH not associated with antithrombotic drug use
Intervention
hemostatic drugs
Comparator
standard care
Outcomes
PICO 40.1
Population
For adults with acute ICH associated with antiplatelet drug use
Intervention
hemostatic drugs
Comparator
standard care
Outcomes
PICO 50.1
Population
For adults with ICH associated with anticoagulant drug use
Intervention
hemostatic drugs
Comparator
standard care
Outcomes
PICO 60.1
Population
For adults with supratentorial ICH
Intervention
surgical hematoma evacuation
Comparator
conservative management
Outcomes
PICO 70.1
Population
For adults with supratentorial ICH
Intervention
drainage of cerebrospinal fluid (CSF) by using an external ventricular drain (EVD)
Comparator
no EVD
Outcomes
PICO 80.1
Population
For adults with supratentorial ICH
Intervention
EVD with intraventricular thrombolysis
Comparator
EVD with placebo
Outcomes
PICO 90.1
Population
For adults with infratentorial ICH
Intervention
surgical hematoma evacuation
Comparator
conservative management
Outcomes
PICO 100.1
Population
For adults with ICH
Intervention
intracranial pressure (ICP) monitoring
Comparator
no ICP monitoring
Outcomes
PICO 110.1
Population
For adults with ICH
Intervention
nonsurgical interventions to lower ICP
Comparator
standard care or other treatments
Outcomes
PICO 120.1
Population
For adults with ICH
Intervention
prevention and early treatment of fever
Comparator
conventional fever management
Outcomes
PICO 130.1
Population
For adults with ICH
Intervention
physical or pharmacological interventions to prevent deep vein thrombosis/pulmonary embolism (DVT/PE)
Comparator
standard care
Outcomes
PICO 140.1
Population
For adults with ICH
Intervention
prophylactic antiepileptic drugs (AEDs)
Comparator
no AEDs
Outcomes
PICO 150.1
Population
For patients with ICH suffering from an early seizure
Intervention
long-term AEDs
Comparator
no AEDs
Outcomes
PICO 160.1
Population
For adults with ICH
Intervention
corticosteroids
Comparator
standard care
Outcomes
PICO 170.1
Population
For adults with ICH
Intervention
the use of do-not-attemptresuscitation (DNAR) or withdrawal-of-care (WOC) orders
Comparator
no use of DNAR or WOC orders
Outcomes
PICO 180.1
Population
For adults who had suffered an ICH
Intervention
subsequent blood pressure-lowering therapy
Comparator
standard care
Outcomes
PICO 190.1
Population
For adults with ICH who had been on antithrombotic drugs for thrombotic disease before their ICH
Intervention
continuation of antithrombotic drugs
Comparator
discontinuation of antithrombotic drugs
Outcomes