European Stroke Organisation (ESO) Guidelines for the management of extracranial and intracranial artery dissection

Published by St├ęphanie Debette on Nov 17, 2021

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Abstract

Language

en

PICOS

PICO 1.1

Population
patients with symptomatic EAD/IAD with acute ischemic stroke within 4.5 hours of onset
Intervention
intravenous thrombolysis with alteplase
Comparator
no intravenous thrombolysis with alteplase
Outcomes

PICO 2.1

Population
In extracranial artery dissection (EAD) & intracranial artery dissection (IAD) patients with acute ischemic stroke
Intervention
endovascular treatment (stenting and/or thrombectomy)
Comparator
no endovascular treatment (with or without IV thrombolysis)
Outcomes

PICO 3.1

Population
In patients with an intracranial dissecting aneurysm and a subarachnoid hemorrhage (SAH)
Intervention
endovascular or surgical treatment of the aneurysm
Comparator
optimal medical treatment alone
Outcomes

PICO 4.1

Population
patients with an intracranial dissecting aneurysm and isolated headache (no transient ischemic attack [TIA], acute ischemic stroke, or subarachnoid hemorrhage [SAH])
Intervention
endovascular or surgical treatment of the aneurysm
Comparator
optimal medical treatment alone
Outcomes

PICO 5.1

Population
EAD and IAD with ischemic stroke/TIA/retinal ischemia/local signs without SAH
Intervention
anticoagulant therapy
Comparator
antiplatelet therapy
Outcomes

PICO 6.1

Population
EAD and IAD without SAH and with a stenosis or a dissecting aneurysm outside the acute phase
Intervention
Endovascular or surgical treatment of stenosis or dissecting aneurysm
Comparator
Optimal medical treatment
Outcomes