Retningslinjer for antitrombotisk behandling og profylakse (2013, under oppdatering)

Main Editor Per Olav Vandvik
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Last Update Oct 12, 2016
Published Date Oct 12, 2016
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Norwegian Guidelines for Antithrombotic Therapy and Thromboprofylaxis: An adaption and update of Antithrombotic Therapy and the Prevention of Thrombosis, 9th Edition: American College of Chest Physicians Evidence-based Guidelines has been produced with permission from the American College of Chest Physicians (“ACCP”), which is the owner of CHEST and the Antithrombotic Therapy and the Prevention of Thrombosis, 9th Edition: American College of Chest Physicians Evidence-based Guidelines. ACCP and its officers, regents, executive committee members, members, related entities, employees, representatives and other agents (collectively, “ACCP Parties”) played no role in the translation of Norwegian Guidelines for Antithrombotic Therapy and Thromboprofylaxis: An adaption and update of Antithrombotic Therapy and the Prevention of Thrombosis, 9th Edition: American College of Chest Physicians Evidence-based Guidelines from English into Norwegian. The ACCP Parties are not responsible in any capacity for, do not warrant and expressly disclaim all liability for, any content whatsoever in this publication and the use or reliance on any such content, and for the accuracy of the translation of the content, all such responsibility being solely that of the Norwegian Medical Association and the authors as the case may be. Furthermore, the content should not be considered medical advice and is not intended to replace consultation with a qualified medical professional. Under no circumstances shall any of the ACCP Parties be liable for any DIRECT, INDIRECT, INCIDENTAL, SPECIAL or CONSEQUENTIAL DAMAGES, or LOST PROFITS that result, directly or indirectly, from the disclosure or use of any of the content of the Guidelines adapted for dissemination in the MAGIC platform, regardless of legal theory.

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Abstract

PICOS
PICO 1.1
P: Høy kardiovaskulær risiko (i henhold til NORRISK) Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
I: ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
C: Ingen behandling Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
O: Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 2.1
P: Symptomatisk PAD Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
I: ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
C: Ingen behandling Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
O: Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 3.1
P: Symptomatisk PAD og klaudicatio LMWH 87233003, LMWH B01A B, LMWH D006495,
I: Hepariner LMWH 87233003, LMWH B01A B, LMWH D006495,
C: Ingen behandling LMWH 87233003, LMWH B01A B, LMWH D006495,
O: LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 4.1
P: Symptomatisk PAD Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,
I: ASA + klopidogrel Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,
C: ASA Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,
O: Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,

PICO 5.1
P: Perifer bypass Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
I: ASA + dipyridamol Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
C: Ingen behandling Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
O: Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 6.1
P: Sekundær prevensjon etter TIA/slag Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
I: ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
C: Ingen behandling Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
O: Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 2.1
P: Akutt VT LMWH 87233003, LMWH B01A B, LMWH D006495,
I: Parenteral antikoagulasjon LMWH 87233003, LMWH B01A B, LMWH D006495,
C: Ingen behandling LMWH 87233003, LMWH B01A B, LMWH D006495,
O: LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 4.1
P: Behandlingslengde
I: 6-12 mnd
C: 3 mnd
O:

PICO 5.1
P: Postoperativ proksimal DVT eller lungeemboli
I: Forlenget antikoagulasjon
C: Kortvarig antikoagulasjon
O:

PICO 1.1
P: Proksimal DVT i underekstremitet på antikoagulasjonsbehandling
I: Vena cava filter
C: Ingen filter
O:

PICO 7.1
P: Posttrombotisk syndrom
I: Kompresjonsstrømper
C: Ingen kompresjonsstrømper
O:

PICO 8.1
P: Overfladisk tromboflebitt Placebo D015990,
I: Fondaparinuks Placebo D015990,
C: Placebo Placebo D015990,
O: Placebo D015990,

PICO 1.1
P: Akutt iskemisk slag
I: Iv rt-PA < 3timer
C: Ingen trombolyse
O:

PICO 2.1
P: Tromboseprofylakse ved nedsatt bevegelighet LMWH 87233003, LMWH B01A B, LMWH D006495,
I: LMWH/UFH LMWH 87233003, LMWH B01A B, LMWH D006495,
C: Ingen profylakse LMWH 87233003, LMWH B01A B, LMWH D006495,
O: LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 3.1
P: Sekundærprevensjon ved ikke-kardioembolisk iskemis hjerneslag eller TIA
I: Antikoagulantia
C: Platehemmer
O:

PICO 4.1
P: Sinusvenetrombose
I: Antikoagulasjon
C: Ingen behandling
O:

PICO 1.1
P: Moderat kardiovaskulær risiko (i henhold til NORRISK) Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Placebo D015990,
I: ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Placebo D015990,
C: Ingen behandling Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Placebo D015990,
O: Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Placebo D015990,

PICO 2.1
P: Etablert koronarsykdom Chronic cardiovascular disease I25, cardiovascular disease I51.6, Angina Pectoris I20, STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Other acute cardiovascular disease I24, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin 1191, Clopidogrel 32968, cardiovascular disease D002318, Clopidogrel C055162, Aspirin D001241, Aspirin D001241,
I: Klopidogrel og ASA Chronic cardiovascular disease I25, cardiovascular disease I51.6, Angina Pectoris I20, STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Other acute cardiovascular disease I24, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin 1191, Clopidogrel 32968, cardiovascular disease D002318, Clopidogrel C055162, Aspirin D001241, Aspirin D001241,
C: ASA Chronic cardiovascular disease I25, cardiovascular disease I51.6, Angina Pectoris I20, STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Other acute cardiovascular disease I24, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin 1191, Clopidogrel 32968, cardiovascular disease D002318, Clopidogrel C055162, Aspirin D001241, Aspirin D001241,
O: Chronic cardiovascular disease I25, cardiovascular disease I51.6, Angina Pectoris I20, STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Other acute cardiovascular disease I24, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin 1191, Clopidogrel 32968, cardiovascular disease D002318, Clopidogrel C055162, Aspirin D001241, Aspirin D001241,

PICO 3.1
P: Første året etter akutt koronarsyndrom STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
I: Klopidogrel STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
C: ASA STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
O: STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,

PICO 4.1
P: Elektiv PCI med DES Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Clopidogrel C055162, Aspirin D001241, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162,
I: 19mnd klopidogrel og ASA Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Clopidogrel C055162, Aspirin D001241, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162,
C: 12mnd klopidogrel og ASA Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Clopidogrel C055162, Aspirin D001241, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162,
O: Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Clopidogrel C055162, Aspirin D001241, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162,

PICO 5.1
P: Første mnd etter PCI Warfarin 372756006, Aspirin 387458008, Aspirin B01 AC06, Warfarin B01A A03, Aspirin 1191, Warfarin 11289, Aspirin D001241, Warfarin D014859, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,
I: Thienopyridine og ASA Warfarin 372756006, Aspirin 387458008, Aspirin B01 AC06, Warfarin B01A A03, Aspirin 1191, Warfarin 11289, Aspirin D001241, Warfarin D014859, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,
C: Warfarin og ASA Warfarin 372756006, Aspirin 387458008, Aspirin B01 AC06, Warfarin B01A A03, Aspirin 1191, Warfarin 11289, Aspirin D001241, Warfarin D014859, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,
O: Warfarin 372756006, Aspirin 387458008, Aspirin B01 AC06, Warfarin B01A A03, Aspirin 1191, Warfarin 11289, Aspirin D001241, Warfarin D014859, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,

PICO 6.1
P: Systolisk dysfunksjon av venstre ventrikkel Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,
I: Warfarin Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,
C: ASA Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,
O: Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,

PICO 1.1
P: Warfarinbruk perioperativt Warfarin B01A A03, Warfarin 372756006, Warfarin 11289, Warfarin D014859,
I: Stopp >5 dager preoperativt Warfarin B01A A03, Warfarin 372756006, Warfarin 11289, Warfarin D014859,
C: Stopp < 5 dager preoperativt Warfarin B01A A03, Warfarin 372756006, Warfarin 11289, Warfarin D014859,
O: Warfarin B01A A03, Warfarin 372756006, Warfarin 11289, Warfarin D014859,

PICO 2.1
P: Elektiv, ikke-kardial kirurgi hos pasienter med lav kardiovaskulær risiko
I: Kontinuere platehemmer
C: Stoppe platehemmer 7-10 dager preoperativt
O:

PICO 2.1
P: Tromboseprofylakse ved hofte- og kneprotese LMWH 87233003, LMWH B01A B, LMWH D006495,
I: Heparin LMWH 87233003, LMWH B01A B, LMWH D006495,
C: Ingen profylakse LMWH 87233003, LMWH B01A B, LMWH D006495,
O: LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 3.1
P: Tromboseprofylakse ved kneartroskopi LMWH 87233003, LMWH B01A B, LMWH D006495,
I: Heparin LMWH 87233003, LMWH B01A B, LMWH D006495,
C: Ingen profylakse LMWH 87233003, LMWH B01A B, LMWH D006495,
O: LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 1.1
P: Oppstartsdose med warfarin Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, High dose 261829003, Low dose 262459003,
I: 10 mg Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, High dose 261829003, Low dose 262459003,
C: 5 mg Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, High dose 261829003, Low dose 262459003,
O: Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, High dose 261829003, Low dose 262459003,

PICO 3.1
P: Blødningsrisiko ved behandling med enoxaparin og nyresvikt
I: Blødning ved clearance < 30
C: Blødning ved clearance >30
O:

PICO 4.1
P: Høy INR (4.5-10) og ingen blødning
I: Vitamin K
C: Stoppe warfarin
O:

PICO 1.1
P: Atrieflimmer og lav risiko for slag: CHA2DS2-VASc 0 Warfarin B01A A03, Warfarin 372756006, Warfarin 11289, Warfarin D014859,
I: Warfarin Warfarin B01A A03, Warfarin 372756006, Warfarin 11289, Warfarin D014859,
C: Ingen behandling Warfarin B01A A03, Warfarin 372756006, Warfarin 11289, Warfarin D014859,
O: Warfarin B01A A03, Warfarin 372756006, Warfarin 11289, Warfarin D014859,

PICO 2.1
P: Antikoagulasjon før konvertering
I: TØE + forkortet antikoagulasjon
C: Antikoagulasjon > 3 uker
O:

PICO 3.1
P: Atrieflimmer, lav risiko for slag (CHA2DS2-VASc 0) og koronarsykom etter PCI med stent
I: Warfarin+klopidogrel+ASA
C: Klopidogrel+ASA
O:

PICO 2.1
P: Langtidsbehandling av DVT og lungeemboli hos gravide LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
I: LMWH LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
C: Vitamin K antagonist LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
O: LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,

PICO 4.1
P: Tromboseprofylakse ved assistert befruktning
I: LMVH
C: Ingen behandling
O:

PICO 6.1
P: Profylakse ved antifosfolipidsyndrom og habituelle aborter Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
I: UFH + ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
C: ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
O: Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 1.1
P: Inneliggende indremedisinske pasienter med lav risiko LMWH 87233003, LMWH B01A B, LMWH D006495,
I: Profylakse (UFH, LMWH, Fondaparinuks) LMWH 87233003, LMWH B01A B, LMWH D006495,
C: Placebo/ingen behandling LMWH 87233003, LMWH B01A B, LMWH D006495,
O: LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 3.1
P: Passasjerer på langdistansefly, lav risiko
I: Kompresjonsstrømper
C: Ingen strømper
O:

PICO 1.1
P: Tromboseprofylakse hos pasienter med lav risiko LMWH 87233003, LMWH B01A B, LMWH D006495,
I: LMWH LMWH 87233003, LMWH B01A B, LMWH D006495,
C: Ingen behandling LMWH 87233003, LMWH B01A B, LMWH D006495,
O: LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 4.1
P: Mekanisk profylakse (IPCD) hos kraniotomerte
I: Intermittent Compression Device
C: Ingen profylakse
O:

PICO 1.2
P: Moderat kardiovaskulær risiko (i henhold til NORRISK) Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
I: ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
C: Ingen behandling Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
O: Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 2.2
P: Symptomatisk PAD Clopidogrel 108979001, Clopidogrel B01A C04, Clopidogrel 32968, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
I: Klopidogrel Clopidogrel 108979001, Clopidogrel B01A C04, Clopidogrel 32968, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
C: ASA Clopidogrel 108979001, Clopidogrel B01A C04, Clopidogrel 32968, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
O: Clopidogrel 108979001, Clopidogrel B01A C04, Clopidogrel 32968, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 3.2
P: Klaudikatio intermittens
I: Prostaglandiner
C: Ingen behandling
O:

PICO 4.2
P: Akutt koronarsykdom Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
I: ASA + klopidogrel Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
C: ASA Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
O: Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 5.2
P: Perifer bypass Aspirin 387458008, Aspirin B01 AC06, Clopidogrel 108979001, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
I: ASA + klopidogrel Aspirin 387458008, Aspirin B01 AC06, Clopidogrel 108979001, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
C: ASA Aspirin 387458008, Aspirin B01 AC06, Clopidogrel 108979001, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
O: Aspirin 387458008, Aspirin B01 AC06, Clopidogrel 108979001, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 6.2
P: Sekundær prevensjon etter TIA/slag Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Clopidogrel B01A C04, Clopidogrel 32968, Clopidogrel C055162,
I: Klopidogrel Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Clopidogrel B01A C04, Clopidogrel 32968, Clopidogrel C055162,
C: ASA Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Clopidogrel B01A C04, Clopidogrel 32968, Clopidogrel C055162,
O: Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Clopidogrel B01A C04, Clopidogrel 32968, Clopidogrel C055162,

PICO 4.2
P: Behandlingslengde
I: 4 eller 6 uker
C: 3 eller 6 mnd
O:

PICO 5.2
P: Førstegangs-VT utløst av forbigående, ikke-kirurgisk risikofaktor med høy blødningsrisiko
I: Forlenget antikoagulasjon
C: Kortvarig antikoagulasjon
O:

PICO 6.2
P: DVT i underekstremitet
I: Systemisk trombolyse
C: Standard antikoagulasjon
O:

PICO 1.2
P: Akutt iskemisk slag
I: Iv rt-PA 3-4.5 timer
C: Ingen trombolyse
O:

PICO 2.2
P: Tromboseprofylakse ved nedsatt bevegelighet LMWH 87233003, LMWH B01A B, LMWH D006495,
I: LMWH LMWH 87233003, LMWH B01A B, LMWH D006495,
C: UFH LMWH 87233003, LMWH B01A B, LMWH D006495,
O: LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 1.2
P: Lav kardiovaskulær risiko (i henhold til NORRISK) Aspirin 387458008, Aspirin B01 AC06, Aspirin D001241, Aspirin 1191, Placebo D015990,
I: ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin D001241, Aspirin 1191, Placebo D015990,
C: Ingen behandling Aspirin 387458008, Aspirin B01 AC06, Aspirin D001241, Aspirin 1191, Placebo D015990,
O: Aspirin 387458008, Aspirin B01 AC06, Aspirin D001241, Aspirin 1191, Placebo D015990,

PICO 2.2
P: Etablert koronarsykdom Chronic cardiovascular disease I25, cardiovascular disease I51.6, Angina Pectoris I20, STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Other acute cardiovascular disease I24, Aspirin 387458008, Warfarin 372756006, Aspirin 387458008, cardiovascular disease 49601007, Aspirin B01 AC06, Warfarin B01A A03, Aspirin B01 AC06, Aspirin 1191, Warfarin 11289, Aspirin 1191, Aspirin D001241, Warfarin D014859, Aspirin D001241, cardiovascular disease D002318,
I: Warfarin og ASA Chronic cardiovascular disease I25, cardiovascular disease I51.6, Angina Pectoris I20, STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Other acute cardiovascular disease I24, Aspirin 387458008, Warfarin 372756006, Aspirin 387458008, cardiovascular disease 49601007, Aspirin B01 AC06, Warfarin B01A A03, Aspirin B01 AC06, Aspirin 1191, Warfarin 11289, Aspirin 1191, Aspirin D001241, Warfarin D014859, Aspirin D001241, cardiovascular disease D002318,
C: ASA Chronic cardiovascular disease I25, cardiovascular disease I51.6, Angina Pectoris I20, STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Other acute cardiovascular disease I24, Aspirin 387458008, Warfarin 372756006, Aspirin 387458008, cardiovascular disease 49601007, Aspirin B01 AC06, Warfarin B01A A03, Aspirin B01 AC06, Aspirin 1191, Warfarin 11289, Aspirin 1191, Aspirin D001241, Warfarin D014859, Aspirin D001241, cardiovascular disease D002318,
O: Chronic cardiovascular disease I25, cardiovascular disease I51.6, Angina Pectoris I20, STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Other acute cardiovascular disease I24, Aspirin 387458008, Warfarin 372756006, Aspirin 387458008, cardiovascular disease 49601007, Aspirin B01 AC06, Warfarin B01A A03, Aspirin B01 AC06, Aspirin 1191, Warfarin 11289, Aspirin 1191, Aspirin D001241, Warfarin D014859, Aspirin D001241, cardiovascular disease D002318,

PICO 3.2
P: Første året etter akutt koronarsyndrom STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, cardiovascular disease D002318,
I: Klopidogrel og ASA STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, cardiovascular disease D002318,
C: ASA STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, cardiovascular disease D002318,
O: STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, cardiovascular disease D002318,

PICO 4.2
P: Elektiv PCI med BMS Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Clopidogrel 108979001, Clopidogrel B01A C04, Aspirin B01 AC06, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162,
I: 6-12mnd klopidogrel og ASA Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Clopidogrel 108979001, Clopidogrel B01A C04, Aspirin B01 AC06, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162,
C: 1mnd klopidogrel og ASA Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Clopidogrel 108979001, Clopidogrel B01A C04, Aspirin B01 AC06, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162,
O: Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Clopidogrel 108979001, Clopidogrel B01A C04, Aspirin B01 AC06, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162,

PICO 2.2
P: Elektiv, ikke-kardial kirurgi hos pasienter med moderat-høy kardiovaskulær risiko
I: Kontinuere platehemmer
C: Stoppe platehemmer 7-10 dager preoperativt
O:

PICO 3.2
P: Tromboseprofylakse ved underekstremitetsskade LMWH 87233003, LMWH B01A B, LMWH D006495,
I: Heparin LMWH 87233003, LMWH B01A B, LMWH D006495,
C: Ingen profylakse LMWH 87233003, LMWH B01A B, LMWH D006495,
O: LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 1.2
P: Overlapping mellom warfarin og LMWH Warfarin 372756006, LMWH 87233003, LMWH B01A B, Warfarin B01A A03, Warfarin 11289, LMWH D006495, Warfarin D014859, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
I: Tidlig oppstart warfarin Warfarin 372756006, LMWH 87233003, LMWH B01A B, Warfarin B01A A03, Warfarin 11289, LMWH D006495, Warfarin D014859, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
C: Sen oppstart warfarin Warfarin 372756006, LMWH 87233003, LMWH B01A B, Warfarin B01A A03, Warfarin 11289, LMWH D006495, Warfarin D014859, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
O: Warfarin 372756006, LMWH 87233003, LMWH B01A B, Warfarin B01A A03, Warfarin 11289, LMWH D006495, Warfarin D014859, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,

PICO 3.2
P: Behandling med UFH
I: Vektjustert dosering
C: Fast dosering
O:

PICO 1.2
P: Atrieflimmer og moderat risiko for slag: CHA2DS2-VASc 1 Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
I: Warfarin Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
C: Ingen behandling Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
O: Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,

PICO 3.2
P: Atrieflimmer, moderat risiko for slag (CHA2DS2-VASc 1) og koronarsykom etter PCI med stent Warfarin 372756006, Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Warfarin 11289, Warfarin D014859, Clopidogrel C055162, Aspirin D001241, Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162,
I: Warfarin+klopidogrel+ASA Warfarin 372756006, Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Warfarin 11289, Warfarin D014859, Clopidogrel C055162, Aspirin D001241, Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162,
C: Klopidogrel+ASA Warfarin 372756006, Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Warfarin 11289, Warfarin D014859, Clopidogrel C055162, Aspirin D001241, Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162,
O: Warfarin 372756006, Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Warfarin 11289, Warfarin D014859, Clopidogrel C055162, Aspirin D001241, Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162,

PICO 4.2
P: Tromboseprofylakse ved OHSS
I: LMVH
C: Ingen behandling
O:

PICO 6.2
P: Profylakse ved habituell abort uten kjent trombofili Aspirin 387458008, LMWH 87233003, Aspirin B01 AC06, LMWH B01A B, Aspirin 1191, Aspirin D001241, LMWH D006495,
I: LMWH + ASA Aspirin 387458008, LMWH 87233003, Aspirin B01 AC06, LMWH B01A B, Aspirin 1191, Aspirin D001241, LMWH D006495,
C: Ingen behandling Aspirin 387458008, LMWH 87233003, Aspirin B01 AC06, LMWH B01A B, Aspirin 1191, Aspirin D001241, LMWH D006495,
O: Aspirin 387458008, LMWH 87233003, Aspirin B01 AC06, LMWH B01A B, Aspirin 1191, Aspirin D001241, LMWH D006495,

PICO 1.2
P: Inneliggende indremedisinske pasienter med høy risiko LMWH 87233003, LMWH B01A B, LMWH D006495,
I: Profylakse (UFH, LMWH, Fondaparinuks) LMWH 87233003, LMWH B01A B, LMWH D006495,
C: Placebo/ingen behandling LMWH 87233003, LMWH B01A B, LMWH D006495,
O: LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 3.2
P: Asymptomatisk trombofili Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
I: ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
C: Ingen behandling Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
O: Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 1.2
P: Tromboseprofylakse hos pasienter med lav risiko
I: Kompresjonsstrømper
C: Ingen behandling
O:

PICO 4.2
P: Mekanisk profylakse hos kraniotomerte
I: Intermittent Compression Device
C: Kompresjonsstrømper
O:

PICO 5.2
P: Tromboseprofylakse ved traumekirurgi hos pasienter med lav tromboserisiko LMWH 87233003, LMWH B01A B, LMWH D006495,
I: LMWH LMWH 87233003, LMWH B01A B, LMWH D006495,
C: Ingen profylakse LMWH 87233003, LMWH B01A B, LMWH D006495,
O: LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 2.3
P: Symptomatisk PAD Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Clopidogrel C055162, Aspirin D001241, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
I: ASA + klopidogrel Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Clopidogrel C055162, Aspirin D001241, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
C: ASA Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Clopidogrel C055162, Aspirin D001241, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
O: Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Clopidogrel C055162, Aspirin D001241, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 3.3
P: Kritisk iskemi
I: Prostanoider
C: Placebo
O:

PICO 5.3
P: Kunstgraft under kneet Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,
I: ASA + klopidogrel Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,
C: ASA Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,
O: Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,

PICO 6.3
P: Sekundær prevensjon etter TIA/slag Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
I: ASA + dipyridamol Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
C: ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
O: Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 2.3
P: Akutt VT LMWH 87233003, LMWH B01A B, LMWH D006495, LMWH 87233003, LMWH B01A B, LMWH D006495,
I: LMWH en gang daglig LMWH 87233003, LMWH B01A B, LMWH D006495, LMWH 87233003, LMWH B01A B, LMWH D006495,
C: LMWH to ganger daglig LMWH 87233003, LMWH B01A B, LMWH D006495, LMWH 87233003, LMWH B01A B, LMWH D006495,
O: LMWH 87233003, LMWH B01A B, LMWH D006495, LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 5.3
P: Førstegangs-VT utløst av forbigående, ikke-kirurgisk risikofaktor med lav-moderat blødningsrisiko
I: Forlenget antikoagulasjon
C: Kortvarig antikoagulasjon
O:

PICO 6.3
P: Akutt lungeemboli, lav risiko
I: Systemisk trombolyse
C: Standard antikoagulasjon
O:

PICO 1.3
P: Akutt iskemisk slag
I: Iv rt-PA >4.5 timer
C: Ingen trombolyse
O:

PICO 2.3
P: Tromboseprofylakse ved nedsatt bevegelighet
I: Kompresjonsstrømper
C: Ingen strømper
O:

PICO 1.3
P: Høy kardiovaskulær risiko (i henhold til NORRISK) Aspirin B01 AC06, , Aspirin 1191, Aspirin D001241,
I: ASA Aspirin B01 AC06, , Aspirin 1191, Aspirin D001241,
C: Ingen behandling Aspirin B01 AC06, , Aspirin 1191, Aspirin D001241,
O: Aspirin B01 AC06, , Aspirin 1191, Aspirin D001241,

PICO 3.3
P: Første året etter akutt koronarsyndrom STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
I: Ticagrelor og ASA STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
C: Klopidogrel og ASA STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
O: STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,

PICO 4.3
P: Fremreveggsinfarkt med venstre ventrikkeltrombe
I: Warfarin, ASA og klopidogrel
C: Klopidogrel og ASA
O:

PICO 1.3
P: Pasienter med lav tromboserisiko LMWH 87233003, LMWH B01A B, LMWH D006495,
I: "Bridging" med UFH/LMWH LMWH 87233003, LMWH B01A B, LMWH D006495,
C: Ingen "bridging" LMWH 87233003, LMWH B01A B, LMWH D006495,
O: LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 3.3
P: Screening av DVT
I: Rutinemessig UL før utskrivelse
C: Ingen screening
O:

PICO 1.3
P: Farmakogenetisk testing før oppstart warfarin
I: Dosering basert på genetisk testing
C: Standard dosering
O:

PICO 1.3
P: Atrieflimmer og høy risiko for slag: CHA2DS2-VASc 2 eller høyere Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
I: Warfarin Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
C: Ingen behandling Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
O: Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,

PICO 3.3
P: Atrieflimmer, høy risiko for slag (CHA2DS2-VASc 2 eller høyere) og koronarsykom etter PCI med stent Warfarin 372756006, Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Warfarin B01A A03, Aspirin 1191, Clopidogrel 32968, Warfarin 11289, Aspirin D001241, Clopidogrel C055162, Warfarin D014859, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162,
I: Warfarin+klopidogrel+ASA Warfarin 372756006, Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Warfarin B01A A03, Aspirin 1191, Clopidogrel 32968, Warfarin 11289, Aspirin D001241, Clopidogrel C055162, Warfarin D014859, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162,
C: Klopidogrel+ASA Warfarin 372756006, Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Warfarin B01A A03, Aspirin 1191, Clopidogrel 32968, Warfarin 11289, Aspirin D001241, Clopidogrel C055162, Warfarin D014859, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162,
O: Warfarin 372756006, Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Warfarin B01A A03, Aspirin 1191, Clopidogrel 32968, Warfarin 11289, Aspirin D001241, Clopidogrel C055162, Warfarin D014859, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162,

PICO 4.3
P: Tromboseprofylakse ved tidligere tromboemboli: Lav risiko
I: LMVH
C: Ingen behandling
O:

PICO 6.3
P: Profylakse mot preeklampsi hos gravide uten kjent trombofili Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
I: ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
C: Ingen behandling Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
O: Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 1.3
P: Inneliggende indremedisinske pasienter med lav risiko
I: Kompresjonsstrømper
C: Ingen behandling
O:

PICO 2.3
P: Pasienter med malign sykdom og samtidig CVK
I: Heparin
C: Ingen antikoagulasjon
O:

PICO 1.3
P: Tromboseprofylakse hos pasienter med moderat risiko LMWH 87233003, LMWH B01A B, LMWH D006495,
I: LMWH LMWH 87233003, LMWH B01A B, LMWH D006495,
C: Ingen behandling LMWH 87233003, LMWH B01A B, LMWH D006495,
O: LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 4.3
P: Tromboseprofylakse hos kraniotomerte LMWH 87233003, LMWH B01A B, LMWH D006495,
I: LMWH LMWH 87233003, LMWH B01A B, LMWH D006495,
C: Ingen behandling LMWH 87233003, LMWH B01A B, LMWH D006495,
O: LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 5.3
P: Tromboseprofylakse ved traumekirurgi hos pasienter med høy tromboserisiko LMWH 87233003, LMWH B01A B, LMWH D006495,
I: LMWH LMWH 87233003, LMWH B01A B, LMWH D006495,
C: Ingen profylakse LMWH 87233003, LMWH B01A B, LMWH D006495,
O: LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 2.4
P: Symptomatisk PAD Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
I: Warfarin + ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
C: ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
O: Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 3.4
P: Akutt iskemi
I: Trombolyse
C: Kirurgi
O:

PICO 5.4
P: Kirurgisk revaskularisering Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
I: Warfarin Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
C: ASA Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
O: Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 6.4
P: Sekundær prevensjon etter TIA/slag
I: ASA + dipyridamol
C: Klopidogrel
O:

PICO 5.4
P: Førstegangs spontan trombose med lav-moderat blødningsrisiko
I: Forlenget antikoagulasjon
C: Kortvarig antikoagulasjon
O:

PICO 6.4
P: Akutt lungeemboli, høy risiko
I: Systemisk trombolyse
C: Standard antikoagulasjon
O:

PICO 1.4
P: Akutt iskemisk slag
I: IA trombolyse
C: Ingen trombolyse
O:

PICO 2.4
P: Tromboseprofylakse ved hjerneblødning og nedsatt bevegelighet
I: LMWH/UFH
C: Ingen profylakse
O:

PICO 3.4
P: Første året etter akutt koronarsyndrom med PCI STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
I: Prasugrel og ASA STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
C: Klopidogrel og ASA STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
O: STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,

PICO 4.4
P: Elektiv PCI med DES Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Clopidogrel C055162, Aspirin D001241, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162,
I: Kortvarig behandling med ASA+klopidogrel Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Clopidogrel C055162, Aspirin D001241, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162,
C: Langvarig behandling med ASA + klopidogrel Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Clopidogrel C055162, Aspirin D001241, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162,
O: Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Clopidogrel C055162, Aspirin D001241, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162,

PICO 1.4
P: Tannprosedyre Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
I: Warfarin + lokal hemostatisk medikament Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
C: Stopp warfarin 2-3 dager preoperativt Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
O: Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,

PICO 1.4
P: Hyppighet av INR-kontroll
I: INR-kontroll > 4 uker
C: INR-kontroll hver 4. uke
O:

PICO 1.4
P: Atrieflimmer og lav risiko for slag: CHA2DS2-VASc 0 Rivaroxiban B01A X06, Apixaban B01A F02, Dabigatran B01A E07, Dabigatran 1037042, Rivaroxiban C503223, Apixaban C522181, Dabigatran C554682, Warfarin D014859, Warfarin 11289, Warfarin B01A A03, LMWH 87233003,
I: Nye perorale antikoagulantia Rivaroxiban B01A X06, Apixaban B01A F02, Dabigatran B01A E07, Dabigatran 1037042, Rivaroxiban C503223, Apixaban C522181, Dabigatran C554682, Warfarin D014859, Warfarin 11289, Warfarin B01A A03, LMWH 87233003,
C: Warfarin Rivaroxiban B01A X06, Apixaban B01A F02, Dabigatran B01A E07, Dabigatran 1037042, Rivaroxiban C503223, Apixaban C522181, Dabigatran C554682, Warfarin D014859, Warfarin 11289, Warfarin B01A A03, LMWH 87233003,
O: Rivaroxiban B01A X06, Apixaban B01A F02, Dabigatran B01A E07, Dabigatran 1037042, Rivaroxiban C503223, Apixaban C522181, Dabigatran C554682, Warfarin D014859, Warfarin 11289, Warfarin B01A A03, LMWH 87233003,

PICO 4.4
P: Tromboseprofylakse ved tidligere tromboemboli: Moderat-høy risiko
I: LMVH
C: Ingen behandling
O:

PICO 6.4
P: Profylakse ved habituell abort uten kjent trombofili Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
I: ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
C: Ingen behandling Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
O: Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 1.4
P: Inneliggende indremedisinske pasienter med høy risiko
I: Kompresjonsstrømper
C: Ingen behandling
O:

PICO 2.4
P: Pasienter med malign kreftsykdom, men uten andre indikasjoner for antikoagulasjon
I: Heparin
C: Ingen antikoagulasjon
O:

PICO 1.4
P: Tromboseprofylakse hos pasienter med høy risiko LMWH 87233003, LMWH B01A B, LMWH D006495,
I: LMWH LMWH 87233003, LMWH B01A B, LMWH D006495,
C: Ingen behandling LMWH 87233003, LMWH B01A B, LMWH D006495,
O: LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 4.4
P: Mekanisk (IPCD) + medikamentell profylakse hos kraniotomerte
I: IPCD + heparin
C: IPCD
O:

PICO 5.4
P: Tromboseprofylakse ved traumekirurgi
I: Kompresjonsstrømper
C: Ingen profylakse
O:

PICO 5.5
P: Venegraft til leggearterie Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
I: Warfarin Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
C: ASA Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
O: Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 6.5
P: Sekundær prevensjon etter TIA/slag Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Clopidogrel B01A C04, Clopidogrel 32968, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
I: ASA + klopidogrel Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Clopidogrel B01A C04, Clopidogrel 32968, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
C: Klopidogrel Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Clopidogrel B01A C04, Clopidogrel 32968, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
O: Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Clopidogrel B01A C04, Clopidogrel 32968, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 2.5
P: Langtidsbehandling hos pasienter uten kreft LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
I: LMWH LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
C: Warfarin LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
O: LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,

PICO 5.5
P: Førstegangs spontan trombose med høy blødningsrisiko
I: Forlenget antikoagulasjon
C: Kortvarig antikoagulasjon
O:

PICO 6.5
P: Ileofemoral DVT
I: Kirurgisk trombektormi
C: Standard antikoagulasjon
O:

PICO 1.5
P: Akutt iskemisk slag
I: IV + IA trombolyse
C: IV trombolyse
O:

PICO 2.5
P: Tromboseprofylakse ved hjerneblødning og nedsatt bevegelighet
I: Tidlig profylakse (dag 2-4)
C: Sen profylakse
O:

PICO 3.5
P: Første året etter akutt koronarsyndrom, medikamentelt behandlet STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
I: Prasugrel og ASA STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
C: Klopidogrel og ASA STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
O: STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,

PICO 1.5
P: Vitamin K supplement til pasienter på warfarin
I: Vitamin K supplement
C: Ingen supplement
O:

PICO 1.5
P: Atrieflimmer og moderat risiko for slag: CHA2DS2-VASc 1 Dabigatran B01A E07, Apixaban B01A F02, Rivaroxiban B01A X06, Warfarin B01A A03, Warfarin 372756006, Warfarin 11289, Warfarin D014859, Dabigatran C554682, Apixaban C522181, Rivaroxiban C503223, Dabigatran 1037042,
I: Nye perorale antikoagulantia Dabigatran B01A E07, Apixaban B01A F02, Rivaroxiban B01A X06, Warfarin B01A A03, Warfarin 372756006, Warfarin 11289, Warfarin D014859, Dabigatran C554682, Apixaban C522181, Rivaroxiban C503223, Dabigatran 1037042,
C: Warfarin Dabigatran B01A E07, Apixaban B01A F02, Rivaroxiban B01A X06, Warfarin B01A A03, Warfarin 372756006, Warfarin 11289, Warfarin D014859, Dabigatran C554682, Apixaban C522181, Rivaroxiban C503223, Dabigatran 1037042,
O: Dabigatran B01A E07, Apixaban B01A F02, Rivaroxiban B01A X06, Warfarin B01A A03, Warfarin 372756006, Warfarin 11289, Warfarin D014859, Dabigatran C554682, Apixaban C522181, Rivaroxiban C503223, Dabigatran 1037042,

PICO 4.5
P: Tromboseprofylakse ved homozygot f. V Leiden og protrombin 20210A mutasjon
I: LMVH
C: Ingen behandling
O:

PICO 1.5
P: Inneliggende pasienter med redusert mobilitet
I: Forlenget profylakse etter utskrivelse
C: Standard profylakse
O:

PICO 2.5
P: Pasienter med malign kreftsykdom, men uten andre indikasjoner for antikoagulasjon
I: Peroral antikoagulasjon
C: Ingen antikoagulasjon
O:

PICO 1.5
P: Tromboseprofylakse hos pasienter med moderat risiko
I: Kompresjonsstrømper
C: Ingen behandling
O:

PICO 4.5
P: Tromboseprofylakse ved spinalkirurgi: Lav risiko
I: Kompresjonsstrømper
C: Ingen profylakse
O:

PICO 5.5
P: Tromboseprofylakse ved traumekirurgi LMWH 87233003, LMWH B01A B, LMWH D006495,
I: Mekanisk + medikamentell profylakse LMWH 87233003, LMWH B01A B, LMWH D006495,
C: Medikamentell profylakse LMWH 87233003, LMWH B01A B, LMWH D006495,
O: LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 2.6
P: Langtidsbehandling hos pasienter med ikke-metastasert kreft LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
I: LMWH LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
C: Warfarin LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
O: LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,

PICO 5.6
P: Annengangs spontan trombose med lav blødningsrisiko
I: Forlenget antikoagulasjon
C: Kortvarig antikoagulasjon
O:

PICO 6.6
P: Ileofemoral DVT
I: Kateterbasert trombolyse
C: Standard antikoagulasjon
O:

PICO 1.6
P: Akutt iskemisk slag
I: Mekanisk trombektomi
C: Standard medikamentell behandling
O:

PICO 3.6
P: Første året etter akutt koronarsyndrom STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
I: Rivaroksaban 2,5 mg x 2 STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
C: Placebo STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
O: STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,

PICO 1.6
P: Hjemmemåling av INR
I: Hjemmemåling
C: Standard testing på laboratorium
O:

PICO 1.6
P: Atrieflimmer og høy risiko for slag: CHA2DS2-VASc 2 eller høyere Dabigatran B01A E07, Rivaroxiban B01A X06, Apixaban B01A F02, Warfarin B01A A03, Apixaban C522181, Rivaroxiban C503223, Dabigatran C554682, Warfarin 11289, Warfarin D014859, Warfarin 372756006, Dabigatran 1037042,
I: Nye perorale antikoagulantia Dabigatran B01A E07, Rivaroxiban B01A X06, Apixaban B01A F02, Warfarin B01A A03, Apixaban C522181, Rivaroxiban C503223, Dabigatran C554682, Warfarin 11289, Warfarin D014859, Warfarin 372756006, Dabigatran 1037042,
C: Warfarin Dabigatran B01A E07, Rivaroxiban B01A X06, Apixaban B01A F02, Warfarin B01A A03, Apixaban C522181, Rivaroxiban C503223, Dabigatran C554682, Warfarin 11289, Warfarin D014859, Warfarin 372756006, Dabigatran 1037042,
O: Dabigatran B01A E07, Rivaroxiban B01A X06, Apixaban B01A F02, Warfarin B01A A03, Apixaban C522181, Rivaroxiban C503223, Dabigatran C554682, Warfarin 11289, Warfarin D014859, Warfarin 372756006, Dabigatran 1037042,

PICO 4.6
P: Tromboprofylakse ved heterozygot faktor V Leiden og protrombin 20210A mutasjon og familieanamnese, kombinasjon Leiden og protrombin
I: LMVH
C: Ingen behandling
O:

PICO 1.6
P: Kritisk syke LMWH 87233003, LMWH B01A B, LMWH D006495, Placebo D015990,
I: LMWH LMWH 87233003, LMWH B01A B, LMWH D006495, Placebo D015990,
C: Placebo LMWH 87233003, LMWH B01A B, LMWH D006495, Placebo D015990,
O: LMWH 87233003, LMWH B01A B, LMWH D006495, Placebo D015990,

PICO 2.6
P: Polikliniske kreftpasienter under pågående cytostatikabehandling
I: LMWH
C: Placebo
O:

PICO 1.6
P: Tromboseprofylakse hos pasienter med høy risiko
I: Kompresjonsstrømper
C: Ingen behandling
O:

PICO 4.6
P: Tromboseprofylakse ved spinalkirurgi: Moderat risiko
I: Kompresjonsstrømper
C: Ingen profylakse
O:

PICO 2.7
P: Langtidsbehandling hos pasienter med metastasert kreft LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
I: LMWH LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
C: Warfarin LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
O: LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,

PICO 5.7
P: Annengangs spontan trombose med moderat-høy blødningsrisiko
I: Forlenget antikoagulasjon
C: Kortvarig antikoagulasjon
O:

PICO 1.7
P: Akutt iskemisk slag
I: Mekanisk trombektomi
C: Ingen trombektomi
O:

PICO 3.7
P: Første året etter akutt koronarsyndrom STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
I: Rivaroksaban 5 mg x 2 STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
C: Placebo STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
O: STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,

PICO 1.7
P: Beslutningsstøtte til dosering av warfarin
I: Beslutningsstøtte
C: Manuell dosering
O:

PICO 1.7
P: Atrieflimmer og lav risiko for slag: CHA2DS2-VASc 0 Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
I: ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
C: Ingen behandling Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
O: Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 4.7
P: Tromboseprofylakse ved antitrombinmagnel med eller uten familieanamnese
I: LMVH
C: Ingen behandling
O:

PICO 1.7
P: Inneliggende indremedisinske pasienter Apixaban B01A F02, Apixaban C522181, LMWH 87233003, LMWH B01A B, LMWH D006495,
I: Apixaban Apixaban B01A F02, Apixaban C522181, LMWH 87233003, LMWH B01A B, LMWH D006495,
C: LMWH Apixaban B01A F02, Apixaban C522181, LMWH 87233003, LMWH B01A B, LMWH D006495,
O: Apixaban B01A F02, Apixaban C522181, LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 1.7
P: Tromboseprofylakse hos pasienter med lav risiko LMWH 87233003, LMWH B01A B, LMWH D006495,
I: Mekanisk profylakse LMWH 87233003, LMWH B01A B, LMWH D006495,
C: LMWH LMWH 87233003, LMWH B01A B, LMWH D006495,
O: LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 4.7
P: Tromboseprofylakse ved spinalkirurgi: Høy risiko
I: Kompresjonsstrømper
C: Ingen profylakse
O:

PICO 2.8
P: Akutt og langtidsbehandling Rivaroxiban B01A X06, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006, LMWH D006495, Warfarin D014859,
I: Rivaroksaban Rivaroxiban B01A X06, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006, LMWH D006495, Warfarin D014859,
C: Warfarin+LMWH Rivaroxiban B01A X06, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006, LMWH D006495, Warfarin D014859,
O: Rivaroxiban B01A X06, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006, LMWH D006495, Warfarin D014859,

PICO 5.8
P: Førstegangs spontan trombose med lav-moderat blødningsrisiko
I: ASA som langtidsprofylakse
C: Ingen behandling
O:

PICO 1.8
P: Akutt iskemisk slag Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
I: ASA <48 timer Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
C: Ingen ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
O: Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 2.8
P: Tromboseprofylakse ved hoftefraktur LMWH 87233003, LMWH B01A B, LMWH D006495,
I: Heparin LMWH 87233003, LMWH B01A B, LMWH D006495,
C: Ingen profylakse LMWH 87233003, LMWH B01A B, LMWH D006495,
O: LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 1.8
P: Optimalt INR-nivå
I: INR > 3
C: INR 2-3
O:

PICO 1.8
P: Atrieflimmer og moderat risiko for slag: CHA2DS2-VASc 1 Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
I: ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
C: Ingen behandling Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
O: Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 4.8
P: Tromboprofylakse ved protein C og S mangel og familieanamnese
I: LMVH
C: Ingen behandling
O:

PICO 1.8
P: Indremedisinske pasienter med indikasjon for profylakse
I: Rivaroksaban
C: LMWH
O:

PICO 1.8
P: Tromboseprofylakse hos pasienter med moderat risiko LMWH 87233003, LMWH B01A B, LMWH D006495,
I: Mekanisk profylakse LMWH 87233003, LMWH B01A B, LMWH D006495,
C: LMWH LMWH 87233003, LMWH B01A B, LMWH D006495,
O: LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 4.8
P: Tromboseprofylakse ved spinalkirurgi: Moderat risiko
I: LMWH
C: Ingen profylakse
O:

PICO 2.9
P: Utvidet behandling Rivaroxiban B01A X06, Rivaroxiban C503223, Placebo D015990,
I: Rivaroksaban Rivaroxiban B01A X06, Rivaroxiban C503223, Placebo D015990,
C: Placebo Rivaroxiban B01A X06, Rivaroxiban C503223, Placebo D015990,
O: Rivaroxiban B01A X06, Rivaroxiban C503223, Placebo D015990,

PICO 1.9
P: Akutt iskemisk slag Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
I: Antikoagulantia Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
C: Platehemmer Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
O: Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,

PICO 1.9
P: Optimalt INR-nivå
I: INR < 2
C: INR 2-3
O:

PICO 1.9
P: Atrieflimmer og høy risiko for slag: CHA2DS2-VASc 2 eller høyere Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
I: ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
C: Ingen behandling Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
O: Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 4.9
P: Tromboseprofylakse ved keisersnitt hos gravide med lav risiko
I: LMVH
C: Ingen behandling
O:

PICO 1.9
P: Indremedisinske pasienter med indikasjon for profylakse
I: Rivaroksaban
C: Placebo
O:

PICO 1.9
P: Tromboseprofylakse hos pasienter med høy risiko LMWH 87233003, LMWH B01A B, LMWH D006495,
I: Mekanisk profylakse LMWH 87233003, LMWH B01A B, LMWH D006495,
C: LMWH LMWH 87233003, LMWH B01A B, LMWH D006495,
O: LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 4.9
P: Tromboseprofylakse ved spinalkirurgi: Høy risiko
I: LMWH
C: Ingen profylakse
O:

PICO 2.10
P: Langtidsbehandling Dabigatran B01A E07, Dabigatran 1037042, Dabigatran C554682, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
I: Dabigatran Dabigatran B01A E07, Dabigatran 1037042, Dabigatran C554682, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
C: Warfarin Dabigatran B01A E07, Dabigatran 1037042, Dabigatran C554682, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
O: Dabigatran B01A E07, Dabigatran 1037042, Dabigatran C554682, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,

PICO 1.10
P: Pasienter med antifosfolipidsyndrom og lav risiko
I: Høy INR
C: Moderat INR
O:

PICO 1.10
P: Atrieflimmer og lav risiko for slag: CHA2DS2-VASc 0 Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
I: Warfarin Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
C: ASA Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
O: Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 4.10
P: Tromboseprofylakse ved keisersnitt hos gravide med høy risiko
I: LMVH
C: Ingen behandling
O:

PICO 1.10
P: Tromboseprofylakse hos pasienter med lav risiko LMWH 87233003, LMWH B01A B, LMWH D006495,
I: Heparin + kompresjonsstrømper LMWH 87233003, LMWH B01A B, LMWH D006495,
C: LMWH eller UFH LMWH 87233003, LMWH B01A B, LMWH D006495,
O: LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 2.11
P: Langtidsbehandling Rivaroxiban B01A X06, Dabigatran B01A E07, Dabigatran 1037042, Rivaroxiban C503223, Dabigatran C554682, Warfarin D014859, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006,
I: Rivaroksaban eller dabigatran Rivaroxiban B01A X06, Dabigatran B01A E07, Dabigatran 1037042, Rivaroxiban C503223, Dabigatran C554682, Warfarin D014859,