COVID-19 rapid guideline: Managing COVID-19

Published by NICE on Jan 10, 2022

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Abstract

Language

en

PICOS

PICO 1.1

Population
People with confirmed or suspected COVID-19
Intervention
Treatment or intermediate dose VTE prophylaxis
Comparator
Standard care (standard or intermediate-dose VTE prophylaxis as defined in the study)
Outcomes

PICO 1.1

Population
People with COVID-19
Intervention
Corticosteroids
Comparator
Control
Outcomes

PICO 1.1

Population
Risk factors for People hospitalised with confirmed COVID-19 and CAPA
Intervention
People with CAPA
Comparator
People without CAPA
Outcomes

PICO 1.2

Population
People with confirmed or suspected COVID-19
Intervention
Treatment dose VTE prophylaxis
Comparator
Standard care (standard or intermediate-dose VTE prophylaxis as defined in the study)
Outcomes

PICO 1.2

Population
Signs and symptoms of people hospitalised with COVID-19 and with CAPA
Intervention
NA
Comparator
NA
Outcomes

PICO 1.3

Population
Diagnostics for CAPA
Intervention
NA
Comparator
NA
Outcomes

PICO 1.3

Population
People with moderate COVID-19
Intervention
Treatment dose VTE prophylaxis
Comparator
Standard dose VTE prophylaxis
Outcomes

PICO 1.4

Population
People with severe COVID-19
Intervention
Treatment dose VTE prophylaxis
Comparator
Standard dose VTE prophylaxis
Outcomes

PICO 1.5

Population
People with severe COVID-19
Intervention
Intermediate dose VTE prophylaxis
Comparator
Standard dose VTE prophylaxis
Outcomes

PICO 1.6

Population
People with severe COVID-19 DUPLICATE
Intervention
Treatment dose VTE prophylaxis
Comparator
Standard dose VTE prophylaxis
Outcomes

PICO 2.1

Population
People with COVID-19 (Hospitalised) ,
Intervention
Casirivimab + Imdevimab ,
Comparator
Usual Care ,
Outcomes
,

PICO 2.1

Population
People hospitalised with COVID-19 and with CAPA
Intervention
Voriconazole
Comparator
Other
Outcomes

PICO 3.1

Population
People with COVID-19
Intervention
Remdesivir
Comparator
Placebo or standard care
Outcomes

PICO 3.2

Population
People with COVID-19
Intervention
Remdesivir 5 days
Comparator
Remdesivir 10 days
Outcomes

PICO 4.1

Population
People with COVID-19
Intervention
Tocilizumab
Comparator
Standard care or placebo
Outcomes

PICO 4.1

Population
People with COVID-19
Intervention
CPAP
Comparator
Conventional oxygen
Outcomes

PICO 4.2

Population
People with COVID-19
Intervention
HFNO
Comparator
Conventional oxygen
Outcomes

PICO 4.2

Population
FROM V12.1 - People with COVID-19
Intervention
Tocilizumab
Comparator
Standard care or placebo
Outcomes

PICO 4.3

Population
People with COVID-19
Intervention
Helmet non-invasive ventilation followed by HFNO
Comparator
HFNO
Outcomes

PICO 5.1

Population
People with COVID-19
Intervention
Sarilumab
Comparator
Standard care
Outcomes

PICO 9.1

Population
People with COVID-19 (Hospitalised)
Intervention
Azithromycin
Comparator
Standard care
Outcomes

PICO 9.2

Population
People with COVID-19 (Outpatients)
Intervention
Azithromycin
Comparator
Standard care
Outcomes

PICO 11.1

Population
People with COVID-19 in hospital
Intervention
Colchicine
Comparator
Placebo or standard care
Outcomes

PICO 11.2

Population
People with COVID-19 in the community
Intervention
Colchicine
Comparator
Placebo
Outcomes

PICO 12.1

Population
People with COVID-19 (Community)
Intervention
Doxycycline plus standard care
Comparator
Standard care
Outcomes

PICO 13.1

Population
People with COVID-19 (Community)
Intervention
Ivermectin
Comparator
Standard care, standard care plus placebo, or placebo
Outcomes

PICO 13.2

Population
People with COVID-19 (Hospitalised)
Intervention
Ivermectin
Comparator
Standard care, standard care plus placebo, or placebo
Outcomes

PICO 14.1

Population
Non-hospitalised adults with COVID-19
Intervention
Inhaled budesonide
Comparator
Standard care, standard care plus placebo, or placebo
Outcomes

PICO 14.2

Population
People with COVID-19 (Hospitalised)
Intervention
Anakinra plus standard care
Comparator
Placebo plus standard care
Outcomes

PICO 14.3

Population
DO NOT USE - People with COVID-10 (Community) ARCHIVE
Intervention
Bamlanivimab + Etesevimab
Comparator
Placebo
Outcomes

PICO 14.4

Population
DO NOT USE -People with COVID-19 (Community) ARCHIVE
Intervention
Sotrovimab
Comparator
Placebo
Outcomes

PICO 14.5

Population
DO NOT USE - People with COVID-19 (Community) ARCHIVE
Intervention
Casirivimab + Imdevimab (SC)
Comparator
Placebo
Outcomes

PICO 14.6

Population
DO NOT USE - People with COVID-19 (Community) ARCHIVE
Intervention
Casirivimab + Imdevimab (IV)
Comparator
Placebo
Outcomes

PICO 14.7

Population
DO NOT USE - People with COVID-19 (Hospitalised) DUPLICATE
Intervention
Casirivimab + Imdevimab
Comparator
Usual Care
Outcomes

PICO 14.8

Population
People with COVID-19 (Community)
Intervention
Casirivimab and Imdevimab (IV)
Comparator
Placebo
Outcomes

PICO 14.9

Population
People with COVID-19 (Community)
Intervention
Casirivimab and Imdevimab (SC)
Comparator
Placebo
Outcomes

PICO 14.10

Population
People with COVID-19 (Community)
Intervention
Sotrovimab
Comparator
Placebo
Outcomes