Hypoxia-inducible factor prolyl hydroxylase Inhibitors (HIF-PHIs) for treatment of anaemia in chronic kidney disease: guidelines for South Asia

Published by Bhaumik S, Tyagi J, Sharma I et al (for South Asia HIF-PHI Guideline Development Group ) on May 22, 2023

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Abstract

Language

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PICOS

PICO 1.1

Population
Management of Anaemia in Non-Dialysis dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors- A Systematic Review
Intervention
Desidustat any dose
Comparator
Darbepoetin Alpha
Outcomes

PICO 1.1

Population
Management of Anaemia in Dialysis-dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors
Intervention
Desidustat
Comparator
Epoetin alpha
Outcomes

PICO 1.2

Population
Management of Anaemia in Non-Dialysis dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors- A Systematic Review
Intervention
Desidustat 100 mg
Comparator
Placebo
Outcomes

PICO 1.3

Population
Management of Anaemia in Non-Dialysis dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors- A Systematic Review
Intervention
Desidustat 150 mg
Comparator
Placebo
Outcomes

PICO 1.4

Population
Management of Anaemia in Non-Dialysis dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors- A Systematic Review
Intervention
Desidustat 200 mg
Comparator
Placebo
Outcomes

PICO 2.1

Population
Management of Anaemia in Non-Dialysis dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors- A Systematic Review
Intervention
Daprodustat any dose
Comparator
Placebo
Outcomes

PICO 2.1

Population
Management of Anaemia in Dialysis-dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors
Intervention
Daprodustat
Comparator
ESA [rhEPO/Darbepoetin Alpha/Epoetin Alpha]
Outcomes

PICO 2.2

Population
Management of Anaemia in Non-Dialysis dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors- A Systematic Review
Intervention
Daprodustat any dose
Comparator
rhEPO (Epoetins or their biosimilars or Darbepoetin)
Outcomes

PICO 2.2

Population
Management of Anaemia in Dialysis-dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors
Intervention
Daprodustat
Comparator
Placebo
Outcomes

PICO 2.3

Population
Management of Anaemia in Dialysis-dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors
Intervention
Daprodustat 10 mg
Comparator
Placebo
Outcomes

PICO 2.4

Population
Management of Anaemia in Dialysis-dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors
Intervention
Daprodustat 15 mg
Comparator
Placebo
Outcomes

PICO 2.5

Population
Management of Anaemia in Dialysis-dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors
Intervention
Daprodustat 25 mg
Comparator
Placebo
Outcomes

PICO 2.6

Population
Management of Anaemia in Dialysis-dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors
Intervention
Daprodustat 30 mg
Comparator
Placebo
Outcomes

PICO 2.7

Population
Management of Anaemia in Dialysis-dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors
Intervention
Daprodustat
Comparator
Placebo for 4 weeks followed by ESA upto 24 weeks
Outcomes

PICO 3.1

Population
Management of Anaemia in Dialysis-dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors
Intervention
Enarodustat any dose
Comparator
Darbepoetin alpha
Outcomes

PICO 3.1

Population
Management of Anaemia in Non-Dialysis dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors- A Systematic Review
Intervention
Enarodustat any dose
Comparator
Darbepoetin alpha
Outcomes

PICO 3.2

Population
Management of Anaemia in Dialysis-dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors
Intervention
Enarodustat any dose
Comparator
Placebo
Outcomes

PICO 3.2

Population
Management of Anaemia in Non-Dialysis dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors- A Systematic Review
Intervention
Enarodustat any dose
Comparator
Placebo
Outcomes

PICO 3.3

Population
Management of Anaemia in Dialysis-dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors
Intervention
Enarodustat 2 mg
Comparator
Placebo
Outcomes

PICO 3.4

Population
Management of Anaemia in Dialysis-dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors
Intervention
Enarodustat 4 mg
Comparator
Placebo
Outcomes

PICO 3.5

Population
Management of Anaemia in Dialysis-dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors
Intervention
Enarodustat 6 mg
Comparator
Placebo
Outcomes

PICO 4.1

Population
Management of Anaemia in Non-Dialysis dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors- A Systematic Review
Intervention
Molidustat any dose
Comparator
Placebo
Outcomes

PICO 4.1

Population
Management of Anaemia in Dialysis-dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors
Intervention
Molidustat
Comparator
ESA [Epoetin alpha/Epoetin beta/ Darbepoetin alpha]
Outcomes

PICO 4.2

Population
Management of Anaemia in Non-Dialysis dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors- A Systematic Review
Intervention
Molidustat any dose
Comparator
Darbepoetin alpha
Outcomes

PICO 5.1

Population
Management of Anaemia in Dialysis-dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors
Intervention
Roxadustat
Comparator
ESA [Epoetin alpha/Darbepoetin alpha]
Outcomes

PICO 5.1

Population
Management of Anaemia in Non-Dialysis dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors- A Systematic Review
Intervention
Roxadustat any dose
Comparator
Placebo
Outcomes

PICO 5.2

Population
Management of Anaemia in Non-Dialysis dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors- A Systematic Review
Intervention
Roxadustat any dose
Comparator
Darbepoetin alpha
Outcomes

PICO 6.1

Population
Management of Anaemia in Non-Dialysis dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors- A Systematic Review
Intervention
Vadadustat any dose
Comparator
Darbepoetin alpha
Outcomes

PICO 6.1

Population
Management of Anaemia in Dialysis-dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors
Intervention
Vadadustat any dose
Comparator
Placebo
Outcomes

PICO 6.2

Population
Management of Anaemia in Non-Dialysis dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors- A Systematic Review
Intervention
Vadadustat any dose
Comparator
Placebo
Outcomes

PICO 6.2

Population
Management of Anaemia in Dialysis-dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors
Intervention
Vadadustat 150 mg
Comparator
Placebo
Outcomes

PICO 6.3

Population
Management of Anaemia in Dialysis-dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors
Intervention
Vadadustat 300 mg
Comparator
Placebo
Outcomes

PICO 6.4

Population
Management of Anaemia in Dialysis-dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors
Intervention
Vadadustat 600 mg
Comparator
Placebo
Outcomes

PICO 6.5

Population
Management of Anaemia in Dialysis-dependent Chronic Kidney Disease with Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors
Intervention
Vadadustat
Comparator
Darbepoetin alpha
Outcomes