Therapeutics and COVID-19: living guideline

Published by World Health Organization on Jan 5, 2024

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Abstract

© World Health Organization 2023

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Suggested citation. Therapeutics and COVID-19: living guideline, 10 November 2023. Geneva: World Health Organization; 2023 (WHO/2019-nCoV/therapeutics/2023.2). Licence: CC BY-NC-SA 3.0 IGO

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Language

en

PICOS

PICO 1.1

Population
Patients with severe or critical COVID-19
Intervention
Systemic corticosteroids
Comparator
Standard care
Outcomes

PICO 1.1

Population
Patients with non-severe COVID-19
Intervention
VV116
Comparator
Standard care
Outcomes

PICO 1.1

Population
Patients with non-severe COVID-19
Intervention
Nirmatrelvir-ritonavir
Comparator
Standard care
Outcomes

PICO 1.2

Population
Patients with severe COVID-19
Intervention
Steroids
Comparator
Standard care
Outcomes

PICO 1.2

Population
Patients with non-severe COVID-19 OUTDATED
Intervention
Nirmatrelvir-ritonavir
Comparator
No nirmatrelvir-ritonavir
Outcomes

PICO 1.3

Population
Patients with critical COVID-19
Intervention
Steroids
Comparator
Standard care
Outcomes

PICO 1.3

Population
Patients with non-severe COVID-19 OUTDATED
Intervention
Nirmatrelvir-ritonavir
Comparator
Molnupiravir
Outcomes

PICO 1.4

Population
Patients with non-severe COVID-19 OUTDATED
Intervention
Remdesivir
Comparator
Nirmatrelvir-ritonavir
Outcomes

PICO 1.4

Population
Patients with COVID-19 infection (all disease severities)
Intervention
Steroids
Comparator
Standard care
Outcomes

PICO 1.5

Population
Patients with critical, severe, non-severe COVID-19 infection [Mortality]
Intervention
Steroids
Comparator
Standard care
Outcomes

PICO 2.1

Population
Patients with non-severe COVID-19
Intervention
Ivermectin
Comparator
Standard care
Outcomes

PICO 2.1

Population
Patients with non-severe COVID-19
Intervention
Remdesivir
Comparator
Standard care
Outcomes

PICO 2.1

Population
Patients with severe or critical COVID-19
Intervention
IL-6 receptor blockers
Comparator
Standard care
Outcomes

PICO 2.2

Population
Patients with COVID-19 (all disease severities)
Intervention
Ivermectin
Comparator
Standard care
Outcomes

PICO 2.2

Population
Patients with COVID-19 infection (all disease severities)
Intervention
IL-6 receptor blockers
Comparator
Standard care
Outcomes

PICO 2.2

Population
Patients with COVID-19 (all disease severities) OUTDATED
Intervention
Remdesivir
Comparator
Standard care
Outcomes

PICO 2.3

Population
Patients with COVID-19 (all disease severities)
Intervention
Tocilizumab + steroids
Comparator
Sarilumab + steroids
Outcomes

PICO 2.3

Population
Patients with non-severe COVID-19 OUTDATED DO NOT USE
Intervention
Remdesivir
Comparator
No remdesivir
Outcomes

PICO 2.4

Population
Patients with COVID-19 infection (mortality subgroup analysis) OUTDATED
Intervention
Remdesivir + usual care
Comparator
Usual care
Outcomes

PICO 2.5

Population
Patients with non-severe COVID-19 infection OUTDATED
Intervention
Remdesivir + usual care
Comparator
Usual care
Outcomes

PICO 2.6

Population
Patients with non-severe COVID-19 infection OUTDATED
Intervention
Remdesivir
Comparator
Nirmatrelvir-ritonavir
Outcomes

PICO 2.7

Population
Patients with non-severe COVID-19 [Feb23 Update] OUTDATED
Intervention
Remdesivir
Comparator
Standard care
Outcomes

PICO 2.8

Population
Patients with non-severe COVID-19 infection OUTDATED
Intervention
Remdesivir
Comparator
Molnupiravir
Outcomes

PICO 2.9

Population
Patients with non-severe COVID-19 OUTDATED
Intervention
Remdesivir
Comparator
Molnupiravir
Outcomes

PICO 2.10

Population
Patients with COVID-19 (all disease severities) - UPDATED 28 JANUARY 2022 OUTDATED
Intervention
Remdesivir
Comparator
Standard care
Outcomes

PICO 3.1

Population
Patients with severe or critical COVID-19
Intervention
Baricitinib
Comparator
Standard care
Outcomes

PICO 3.1

Population
Patients with non-severe COVID-19
Intervention
Molnupiravir
Comparator
Standard care
Outcomes

PICO 3.1

Population
Patients with non-severe COVID-19
Intervention
Convalescent plasma
Comparator
Standard care
Outcomes

PICO 3.2

Population
Patients with severe or critical COVID-19
Intervention
Baricitinib
Comparator
Standard care
Outcomes

PICO 3.2

Population
Patients with severe or critical COVID-19
Intervention
Convalescent plasma
Comparator
Standard care
Outcomes

PICO 3.2

Population
Patients with non-severe COVID-19
Intervention
Molnupiravir
Comparator
Nirmatrelvir-ritonavir
Outcomes

PICO 3.3

Population
Patients with non-severe COVID-19
Intervention
Molnupiravir
Comparator
Remdesivir
Outcomes

PICO 3.3

Population
Patients with severe and critical COVID-19
Intervention
Baricitinib
Comparator
Interleukin-6 receptor blockers
Outcomes

PICO 3.4

Population
Patients with severe or critical COVID-19
Intervention
Ruxolitinib
Comparator
Standard care
Outcomes

PICO 3.4

Population
Patients with non-severe COVID-19
Intervention
Nirmatrelvir-ritonavir
Comparator
Remdesivir
Outcomes

PICO 3.5

Population
Patients with non-severe COVID-19 [ARCHIVE - do not use] OUTDATED
Intervention
Molnupiravir
Comparator
Standard care
Outcomes

PICO 3.5

Population
Patients with severe or critical COVID-19
Intervention
Tofacitinib
Comparator
Standard care
Outcomes

PICO 3.6

Population
Patients with non-severe COVID-19 OUTDATED
Intervention
Molnupiravir
Comparator
Standard care
Outcomes

PICO 3.6

Population
Patients with severe or critical COVID-19 OUTDATED
Intervention
Baricitinib
Comparator
Standard care
Outcomes

PICO 4.1

Population
Patients with non-severe COVID-19
Intervention
Systemic corticosteroids
Comparator
Standard care
Outcomes

PICO 4.1

Population
Patients with severe or critical COVID-19
Intervention
Remdesivir
Comparator
No remdesivir
Outcomes

PICO 4.1

Population
Patients with COVID-19 (all disease severities)
Intervention
Lopinavir-ritonavir
Comparator
Standard care
Outcomes

PICO 4.2

Population
Patients with severe COVID-19
Intervention
Remdesivir
Comparator
No remdesivir
Outcomes

PICO 4.2

Population
Patients with COVID-19 (all disease severities) - UPDATED JANUARY 28 2022 OUTDATED
Intervention
Lopinavir/ritonavir
Comparator
Standard care
Outcomes

PICO 4.3

Population
Patients with critical COVID-19
Intervention
Remdesivir
Comparator
No remdesivir
Outcomes

PICO 4.4

Population
Patients with severe COVID-19 infection OUTDATED
Intervention
Remdesivir + usual care
Comparator
Usual care
Outcomes

PICO 4.5

Population
Patients with critical COVID-19 infection OUTDATED
Intervention
Remdesivir + usual care
Comparator
Usual care
Outcomes

PICO 5.1

Population
Patients with COVID-19 (all disease severities)
Intervention
Hydroxychloroquine
Comparator
Standard care
Outcomes

PICO 5.1

Population
Patients with non-severe COVID-19
Intervention
Fluvoxamine
Comparator
No fluvoxamine
Outcomes

PICO 5.2

Population
Patients with COVID-19 infection (all disease severities) OUTDATED
Intervention
Hydroxychloroquine + azithromycin usual care
Comparator
Usual care
Outcomes

PICO 5.2

Population
Patients with non-severe COVID-19
Intervention
Fluvoxamine
Comparator
Nirmatrelvir-ritonavir
Outcomes

PICO 5.3

Population
Patients with COVID-19 infection (all disease severities) OUTDATED
Intervention
Hydroxychloroquine + usual care
Comparator
Usual care
Outcomes

PICO 5.3

Population
Patients with non-severe COVID-19
Intervention
Fluvoxamine
Comparator
Molnupiravir
Outcomes

PICO 5.4

Population
Patients with non-severe COVID-19
Intervention
Fluvoxamine
Comparator
Remdesivir
Outcomes

PICO 6.1

Population
Patients with non-severe COVID-19 OUTDATED
Intervention
Casirivimab-imdevimab
Comparator
Standard care
Outcomes

PICO 6.1

Population
Patients with non-severe COVID-19 OUTDATED
Intervention
Sotrovimab
Comparator
Standard care
Outcomes

PICO 6.2

Population
Patients with severe or critical COVID-19, seronegative OUTDATED
Intervention
Casirivimab-imdevimab
Comparator
Standard care
Outcomes

PICO 6.2

Population
Patients with non-severe COVID-19 OUTDATED
Intervention
Sotrovimab
Comparator
Casirivimab-imdevimab
Outcomes

PICO 6.3

Population
Patients with severe or critical COVID-19 OUTDATED
Intervention
Casirivimab-imdevimab
Comparator
Standard care
Outcomes

PICO 6.4

Population
BY RISK (not used) - Patients with non-severe COVID-19 OUTDATED
Intervention
Casirivimab and imdevimab
Comparator
No casirivimab and imdevimab
Outcomes

PICO 6.5

Population
Patients with COVID-19 (all severities) OUTDATED
Intervention
Casirivimab and imdevimab
Comparator
No casirivimab and imdevimab
Outcomes

PICO 6.6

Population
Patients with non-severe COVID-19 - UPDATED Feb 9 2022 OUTDATED
Intervention
Casirivimab-imdevimab
Comparator
Standard care
Outcomes

PICO 6.7

Population
Patients with severe or critical COVID-19 - UPDATED 09 FEB 2022 OUTDATED
Intervention
Casirivimab-imdevimab
Comparator
Standard care
Outcomes

PICO 7.1

Population
Patients with non-severe COVID-19
Intervention
Colchicine
Comparator
Standard care
Outcomes

PICO 7.1

Population
Patients with severe COVID-19 OUTDATED
Intervention
Therapeutic anticoagulation
Comparator
Up to prophylactic anticoagulation
Outcomes

PICO 7.2

Population
Patients with critical COVID-19 OUTDATED
Intervention
Therapeutic anticoagulation
Comparator
Up to prophylactic anticoagulation
Outcomes

PICO 7.3

Population
Patients with non-severe COVID-19 OUTDATED
Intervention
Colchicine
Comparator
No colchicine
Outcomes

PICO 7.4

Population
Patients with non-severe COVID-19 OUTDATED
Intervention
Colchicine
Comparator
No colchicine
Outcomes

PICO 7.5

Population
Patients with severe COVID-19 OUTDATED
Intervention
Colchicine
Comparator
No colchicine
Outcomes

PICO 7.6

Population
Patients with severe or critical COVID-19 OUTDATED
Intervention
Janus kinase inhibitors
Comparator
No Janus kinase inhibitor
Outcomes

PICO 7.7

Population
Patients with severe or critical COVID-19 OUTDATED
Intervention
Janus kinase inhibitors
Comparator
Interleukin-6 receptor blockers with glucocorticoids
Outcomes

PICO 7.8

Population
Patients with non-severe COVID-19 OUTDATED
Intervention
Convalescent plasma
Comparator
No convalescent plasma
Outcomes

PICO 7.9

Population
Patients with severe and critical COVID-19 OUTDATED
Intervention
Ruxolitinib
Comparator
Interleukin 6-receptor blockers
Outcomes

PICO 7.10

Population
Patients with severe and critical COVID-19 OUTDATED
Intervention
Tofacitinib
Comparator
Interleukin 6-receptor blockers
Outcomes

PICO 7.11

Population
Patients with non-severe COVID-19 (pairwise for comparison - do NOT use)
Intervention
Colchicine
Comparator
Standard care
Outcomes

PICO 7.12

Population
Patients with severe or critical COVID-19 OUTDATED
Intervention
Therapeutic anticoagulation
Comparator
Intermediate anticoagulation
Outcomes

PICO 7.13

Population
Patients with severe or critical COVID-19 OUTDATED
Intervention
Therapeutic anticoagulation
Comparator
Prophylactic anticoagulation
Outcomes

PICO 7.14

Population
Patients with severe or critical COVID-19 OUTDATED
Intervention
Intermediate anticoagulation
Comparator
Prophylactic anticoagulation
Outcomes