PICOS
PICO 10.1
Population
People without a CRC diagnosis or symptoms that might indicate CRC
Intervention
CRC screening with flexible sigmoidoscopy
Comparator
No screening or usual care
Outcomes
PICO 10.1
Population
Persons without a CRC diagnosis or symptoms that might indicate CRC (with a family history of CRC or no family history of CRC)
Intervention
Index Test 1: Screening for CRC with any of the following: • iFOBT • Faecal biomarkers • Blood-based biomarkers • Any combinations Index Test 2: An alternative screening test or no screening
Comparator
Colonoscopy findings or follow-up outcomes
Outcomes
PICO 10.2
Population
People without a CRC diagnosis or symptoms that might indicate CRC
Intervention
CRC screening with flexible sigmoidoscopy +iFOBT
Comparator
No screening or usual care
Outcomes
PICO 10.3
Population
People without a CRC diagnosis or symptoms that might indicate CRC
Intervention
CRC screening with colonoscopy
Comparator
No screening or usual care
Outcomes
PICO 10.4
Population
People without a CRC diagnosis or symptoms that might indicate CRC by sex
Intervention
CRC screening with flexible sigmoidoscopy
Comparator
No screening or usual care
Outcomes
PICO 10.5
Population
People without a CRC diagnosis or symptoms that might indicate CRC by sex
Intervention
CRC screening with flexible sigmoidoscopy +iFOBT
Comparator
No screening or usual care
Outcomes