Guidelines on the management of critical bleedings in patients with immune thrombocytopenia

Published by Saifur R. Chowdhury, Emily Sirotich, Gordon Guyatt, Donald M. Arnold on May 6, 2024

Disclaimer

Sponsors

Contact

Abstract

Language

en

PICOS

PICO 1.1

Population
ITP patients with critical bleeds (CRITICAL BLEED SYSTEMATIC REVIEW - ADULTS)
Intervention
Corticosteroids
Comparator
No corticosteroids
Outcomes

PICO 1.2

Population
ITP patients with critical bleeds (COHORT STUDY - ADULTS)
Intervention
Corticosteroids
Comparator
No corticosteroids
Outcomes

PICO 1.3

Population
ITP patients (PLATELET RESPONSE SYSTEMATIC REVIEW - ADULTS)
Intervention
High-dose dexamethasone
Comparator
Prednisolone
Outcomes

PICO 1.4

Population
ITP patients (PLATELET RESPONSE SYSTEMATIC REVIEW - ADULTS)
Intervention
Dexamethasone and prednisolone
Comparator
Prednisolone
Outcomes

PICO 1.5

Population
ITP patients with critical bleeds (CRITICAL BLEED SYSTEMATIC REVIEW - CHILDREN)
Intervention
Corticosteroids
Comparator
No corticosteroids
Outcomes

PICO 1.6

Population
ITP patients with critical bleeds (COHORT STUDY - CHILDREN)
Intervention
Corticosteroids
Comparator
No corticosteroids
Outcomes

PICO 1.7

Population
ITP patients (PLATELET RESPONSE SYSTEMATIC REVIEW - CHILDREN)
Intervention
Prednisone
Comparator
Observation/Placebo
Outcomes

PICO 1.8

Population
ITP patients (PLATELET RESPONSE SYSTEMATIC REVIEW - CHILDREN)
Intervention
Methylprednisolone
Comparator
Observation
Outcomes

PICO 1.9

Population
ITP patients (PLATELET RESPONSE SYSTEMATIC REVIEW - CHILDREN)
Intervention
High-dose dexamethasone
Comparator
Prednisone
Outcomes

PICO 2.1

Population
ITP patients with critical bleeds (CRITICAL BLEED SYSTEMATIC REVIEW - ADULTS)
Intervention
IVIG
Comparator
No IVIG
Outcomes

PICO 2.2

Population
ITP patients with critical bleeds (COHORT STUDY - ADULTS)
Intervention
IVIG
Comparator
No IVIG
Outcomes

PICO 2.3

Population
ITP patients (PLATELET RESPONSE SYSTEMATIC REVIEW - ADULTS)
Intervention
IVIG
Comparator
High-dose methylprednisolone
Outcomes

PICO 2.4

Population
ITP patients (PLATELET RESPONSE SYSTEMATIC REVIEW - ADULTS)
Intervention
Anti-D
Comparator
Outcomes

PICO 2.5

Population
ITP patients with critical bleeds (CRITICAL BLEED SYSTEMATIC REVIEW - CHILDREN)
Intervention
IVIG
Comparator
No IVIG
Outcomes

PICO 2.6

Population
ITP patients with critical bleeds (COHORT STUDY - CHILDREN)
Intervention
IVIG
Comparator
No IVIG
Outcomes

PICO 2.7

Population
ITP patients (PLATELET RESPONSE SYSTEMATIC REVIEW - CHILDREN)
Intervention
IVIG
Comparator
Observation
Outcomes

PICO 2.8

Population
ITP patients (PLATELET RESPONSE SYSTEMATIC REVIEW - CHILDREN)
Intervention
IVIG
Comparator
Methylprednisolone
Outcomes

PICO 2.9

Population
ITP patients (PLATELET RESPONSE SYSTEMATIC REVIEW - CHILDREN)
Intervention
IVIG
Comparator
Prednisone
Outcomes

PICO 2.10

Population
ITP patients (PLATELET RESPONSE SYSTEMATIC REVIEW - CHILDREN)
Intervention
IVIG
Comparator
Anti-D
Outcomes

PICO 3.1

Population
ITP patients with critical bleeds (CRITICAL BLEED SYSTEMATIC REVIEW - ADULTS)
Intervention
Platelet transfusions
Comparator
No Platelet transfusions
Outcomes

PICO 3.2

Population
ITP patients with critical bleeds (COHORT STUDY - ADULTS)
Intervention
Platelet transfusions
Comparator
No Platelet transfusions
Outcomes

PICO 3.3

Population
ITP patients with critical bleeds (CRITICAL BLEED SYSTEMATIC REVIEW - CHILDREN)
Intervention
Platelet transfusions
Comparator
No Platelet transfusions
Outcomes

PICO 3.4

Population
ITP patients with critical bleeds (COHORT STUDY - CHILDREN)
Intervention
Platelet transfusions
Comparator
No Platelet transfusions
Outcomes

PICO 3.5

Population
ITP patients (ADULTS AND CHILDREN)
Intervention
Platelet transfusions
Comparator
No Platelet transfusions
Outcomes

PICO 4.1

Population
ITP patients with critical bleeds (CRITICAL BLEED SYSTEMATIC REVIEW - ADULTS)
Intervention
TPO-RAs
Comparator
No TPO-RAs
Outcomes

PICO 4.2

Population
ITP patients with critical bleeds (COHORT STUDY - ADULTS)
Intervention
TPO-RAs
Comparator
No TPO-RAs
Outcomes

PICO 4.3

Population
ITP patients (PLATELET RESPONSE SYSTEMATIC REVIEW - ADULTS)
Intervention
Avatrombopag
Comparator
Placebo
Outcomes

PICO 4.4

Population
ITP patients (PLATELET RESPONSE SYSTEMATIC REVIEW - ADULTS)
Intervention
Eltrombopag
Comparator
Placebo
Outcomes

PICO 4.5

Population
ITP patients (PLATELET RESPONSE SYSTEMATIC REVIEW - ADULTS)
Intervention
High-dose dexamethasone and rhTPO
Comparator
High-dose dexamethasone
Outcomes

PICO 4.6

Population
ITP patients (PLATELET RESPONSE SYSTEMATIC REVIEW - ADULTS)
Intervention
Glucocorticosteroids and rhTPO
Comparator
Glucocorticosteroids
Outcomes

PICO 4.7

Population
ITP patients with critical bleeds (CRITICAL BLEED SYSTEMATIC REVIEW - CHILDREN)
Intervention
TPO-RAs
Comparator
No TPO-RAs
Outcomes

PICO 4.8

Population
ITP patients with critical bleeds (COHORT STUDY - CHILDREN)
Intervention
TPO-RAs
Comparator
No TPO-RAs
Outcomes

PICO 4.9

Population
ITP patients (PLATELET RESPONSE SYSTEMATIC REVIEW - CHILDREN)
Intervention
Eltrombopag
Comparator
Placebo
Outcomes

PICO 5.1

Population
ITP patients with non-critical bleeds (ADULTS)
Intervention
Tranexamic acid
Comparator
No Tranexamic acid
Outcomes

PICO 5.2

Population
ITP patients with non-critical bleeds (CHILDREN)
Intervention
Tranexamic acid
Comparator
No Tranexamic acid
Outcomes

PICO 6.1

Population
ITP patients with bleeding and/or bleeding risks (ADULTS)
Intervention
Recombinant FVIIa
Comparator
No Recombinant FVIIa
Outcomes

PICO 6.2

Population
ITP patients with bleeding and/or bleeding risks (CHILDREN)
Intervention
Recombinant FVIIa
Comparator
No Recombinant FVIIa
Outcomes

PICO 7.1

Population
ITP patients with critical bleeds (CRITICAL BLEED SYSTEMATIC REVIEW - ADULTS)
Intervention
Splenectomy
Comparator
No Splenectomy
Outcomes

PICO 7.2

Population
ITP patients with critical bleeds (CRITICAL BLEED SYSTEMATIC REVIEW - CHILDREN)
Intervention
Splenectomy
Comparator
No Splenectomy
Outcomes