Clinical management of diphtheria: guideline

Published by World Health Organization on Feb 21, 2024

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PICOS

PICO 5.1

Population
Persons with suspected or confirmed diphtheria
Intervention
Macrolide antibiotic
Comparator
Penicillin antibiotic
Outcomes

PICO 5.2

Population
Persons with suspected or confirmed diphtheria for whom diphtheria antitoxin is indicated
Intervention
Sensitivity testing performed prior to administration of diphtheria antitoxin
Comparator
Sensitivity testing not performed prior to administration of diphtheria antitoxin
Outcomes

PICO 5.3

Population
Persons with suspected or confirmed diphtheria for whom diphtheria antitoxin is indicated
Intervention
Escalating doses of diphtheria antitoxin
Comparator
Fixed dose diphtheria antitoxin
Outcomes

PICO 5.4

Population
Persons with suspected or confirmed diphtheria for whom diphtheria antitoxin is indicated
Intervention
Escalating doses of diphtheria antitoxin
Comparator
Fixed dose diphtheria antitoxin
Outcomes

PICO 5.5

Population
Persons with suspected or confirmed diphtheria who are receiving antibiotic treatment
Intervention
Isolation for two days
Comparator
Isolation for longer than two days
Outcomes