Guideline for the prophylactic use of Rh D immunoglobulin in pregnancy care

Published by National Blood Authority on Aug 5, 2024

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ISBN 978-0-6453281-2-7 (electronic copy) 

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Abstract

v1.3:  05/08/2024

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Language

en-au

PICOS

PICO 10.1

Population
Rh D negative pregnant women with no preformed anti-D
Intervention
Universal routine antenatal Rh D immunoprophylaxis (one or two doses)
Comparator
no universal routine antenatal Rh D immunoprophylaxis
Outcomes

PICO 10.2

Population
Rh D negative pregnant women with no preformed anti-D
Intervention
Universal routine antenatal Rh D immunoprophylaxis (one or two doses)
Comparator
no universal routine antenatal Rh D immunoprophylaxis
Outcomes

PICO 10.3

Population
Rh D negative pregnant women with no preformed anti-D
Intervention
Universal routine antenatal Rh D immunoprophylaxis (one dose)
Comparator
Universal routine antenatal Rh D immunoprophylaxis (two doses)
Outcomes

PICO 20.1

Population
Rh D negative pregnant women with no preformed anti-D with a first 12 weeks of pregnancy sensitising event
Intervention
Routine sensitising event immunoprophylaxis
Comparator
Placebo or no sensitising event immunoprophylaxis
Outcomes

PICO 30.1

Population
Rh D negative pregnant women with no preformed anti-D
Intervention
Targeted antenatal Rh D Immunoprophylaxis (based on NIPT)
Comparator
Universal antenatal Rh D immunoprophylaxis
Outcomes

PICO 30.2

Population
Rh D negative pregnant women with no preformed anti-D (for routine or sensitising event immunoprophylaxis)
Intervention
NIP screening for fetal Rh D status
Comparator
Postnatal cord blood testing (or other neonatal sample) for fetal Rh D status or other noninvasive prenatal test for fetal Rh D status
Outcomes

PICO 40.1

Population
Rh D negative pregnant women with increased BMI and no preformed anti-D
Intervention
Increased dose of RAADP
Comparator
Not applicable
Outcomes