Clinical practice guidelines for influenza

Published by World Health Organization on Sep 18, 2024

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This publication is the update of the document published in 2022 entitled “Guidelines for the clinical management of severe illness from influenza virus infections”.


ISBN 978-92-4-009775-9 (electronic version)
ISBN 978-92-4-009776-6 (print version)

 

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CORRIGENDA

 

Clinical practice guidelines for influenza 

 

ISBN 978-92-4-009775-9 (electronic version) 

ISBN 978-92-4-009776-6 (print version) 

 

Table 9.4, lines 3 

Delete: 

Children < 10 years 20 mg single dose for 2 days 

Insert: 

Children < 10 years 20 mg single dose 

  

Annex 1, Flow chart 

Delete: 

Laninamivir 20mg inhaled once daily for 3 days 

Insert: 

Laninamivir 20mg inhaled once daily for 2 days 

  

These corrections have been incorporated into the electronic file on 17 September 2024. 

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Abstract

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PICOS

PICO 10.1

Population
Patients with non-severe influenza
Intervention
Baloxavir
Comparator
Standard care/placebo
Outcomes

PICO 10.1

Population
Persons with suspected influenza
Intervention
Alternative testing strategies
Comparator
Alternative testing strategies
Outcomes

PICO 10.1

Population
Population with exposure to zoonotic influenza virus but without infection
Intervention
Baloxavir
Comparator
Placebo
Outcomes

PICO 10.1

Population
Population with exposure to seasonal influenza virus but without infection
Intervention
Baloxavir
Comparator
Placebo
Outcomes

PICO 10.1

Population
Patients with laboratory-confirmed, non-severe, symptomatic influenza virus infection
Intervention
Antibiotic
Comparator
No antibiotic
Outcomes

PICO 10.1

Population
Patients with severe influenza
Intervention
Oseltamivir
Comparator
Standard care/placebo
Outcomes

PICO 10.1

Population
Patients with severe influenza
Intervention
Systemic corticosteroids
Comparator
No systemic corticosteroids
Outcomes

PICO 20.1

Population
Patients with non-severe influenza
Intervention
Favipiravir
Comparator
Standard care/placebo
Outcomes

PICO 20.1

Population
Population with exposure to zoonotic influenza virus but without infection
Intervention
Laninamivir
Comparator
Placebo
Outcomes

PICO 20.1

Population
Population with exposure to seasonal influenza virus but without infection
Intervention
Laninamivir
Comparator
Placebo
Outcomes

PICO 20.1

Population
Patients with severe influenza
Intervention
Macrolide antibiotics
Comparator
No Macrolide antibiotics
Outcomes

PICO 20.1

Population
Patients with severe influenza
Intervention
Peramivir
Comparator
Standard care/placebo
Outcomes

PICO 30.1

Population
Patients with severe influenza
Intervention
Zanamivir
Comparator
Standard care/placebo
Outcomes

PICO 30.1

Population
Patients with severe influenza
Intervention
mTOR inhibitors
Comparator
Standard care
Outcomes

PICO 30.1

Population
Population with exposure to seasonal influenza virus but without infection
Intervention
Oseltamivir
Comparator
Placebo
Outcomes

PICO 30.1

Population
Population with exposure to zoonotic influenza virus but without infection
Intervention
Oseltamivir
Comparator
Placebo
Outcomes

PICO 30.1

Population
Patients with non-severe influenza
Intervention
Laninamivir
Comparator
Standard care/placebo
Outcomes

PICO 40.1

Population
Patients with severe influenza
Intervention
Combination Non-steroidal anti-inflammatory drugs (NSAIDs) and macrolides
Comparator
No combination Non-steroidal anti-inflammatory drugs (NSAIDs) and macrolides
Outcomes

PICO 40.1

Population
Population with exposure to seasonal influenza virus but without infection
Intervention
Zanamivir
Comparator
Placebo/standard of care
Outcomes

PICO 40.1

Population
Patients with non-severe influenza
Intervention
Oseltamivir
Comparator
Standard care/placebo
Outcomes

PICO 40.1

Population
Population with exposure to zoonotic influenza virus but without infection
Intervention
Zanamivir
Comparator
Placebo/standard of care
Outcomes

PICO 40.2

Population
Patients with severe influenza
Intervention
Non-steroidal anti-inflammatory drugs (NSAIDs)
Comparator
No Non-steroidal anti-inflammatory drugs (NSAIDs)
Outcomes

PICO 50.1

Population
Patients with severe influenza
Intervention
Passive immune therapy
Comparator
No passive immune therapy
Outcomes

PICO 50.1

Population
Patients with non-severe influenza
Intervention
Peramivir
Comparator
Standard care/placebo
Outcomes

PICO 60.1

Population
Patients with non-severe influenza
Intervention
Umifenovir
Comparator
Standard care/placebo
Outcomes

PICO 70.1

Population
Patients with non-severe influenza
Intervention
Zanamivir
Comparator
Standard care/placebo
Outcomes