PICOS
PICO 10.1
Population
Adults with fibromyalgia
Intervention
Pain education
Comparator
Usual care
Outcomes
PICO 10.1
Population
Fibromyalgia - Chronic Primary Pain
Intervention
Milnacipran 100 mg
Comparator
Placebo
Outcomes
PICO 10.1
Population
Fibromyalgia
Intervention
Tramadol + Acetaminophen
Comparator
Placebo
Outcomes
PICO 10.1
Population
adult with chronic pain
Intervention
interprofessional collaboration
Comparator
regular approach
Outcomes
PICO 10.2
Population
Adults with CLBP
Intervention
Pain education
Comparator
Usual care
Outcomes
PICO 10.2
Population
Fibromyalgia - Chronic Primary Pain
Intervention
Milnacipran 200 mg
Comparator
Placebo
Outcomes
PICO 10.2
Population
Fibromyalgia
Intervention
Oxycodone
Comparator
Placebo
Outcomes
PICO 10.3
Population
Adults with CLBP
Intervention
Pain education + physiotherapy
Comparator
Usual care
Outcomes
PICO 10.3
Population
Fibromyalgia - Chronic Primary Pain
Intervention
Duloxetine 60 mg
Comparator
Placebo
Outcomes
PICO 10.4
Population
Adults with chronic pain
Intervention
Motivational interviewing
Comparator
Usual care
Outcomes
PICO 10.4
Population
Fibromyalgia - Chronic Primary Pain
Intervention
Duloxetine 120 mg
Comparator
Placebo
Outcomes
PICO 10.5
Population
Fibromyalgia - Chronic Primary Pain
Intervention
SNRIs (duloxetine, milnacipran) [If pooled]
Comparator
Placebo
Outcomes
PICO 10.6
Population
Fibromyalgia - Chronic Primary Pain
Intervention
Venlafaxine
Comparator
Placebo
Outcomes
PICO 20.1
Population
Adults with fibromyalgia
Intervention
Exercise therapy
Comparator
Usual care
Outcomes
PICO 20.1
Population
Adults with chronic pain
Intervention
Cognitive behavioural therapy
Comparator
usual care or waiting list
Outcomes
PICO 20.1
Population
Adults with chronic pain
Intervention
Mindfulness meditation interventions
Comparator
Treatment as usual, waitlists, no treatment, or other active treatments
Outcomes
PICO 20.1
Population
Chronic Primary Pain - Fybromialgia
Intervention
SSRIs (pooled)
Comparator
Placebo
Outcomes
PICO 20.1
Population
Chronic Low Back Pain
Intervention
Duloxetine (different doses)
Comparator
Placebo
Outcomes
PICO 20.1
Population
CLBP
Intervention
Opioids
Comparator
Placebo
Outcomes
PICO 20.1
Population
Fibromyalgia
Intervention
Opioid
Comparator
Placebo
Outcomes
PICO 20.1
Population
Adults with chronic pain
Intervention
management
Comparator
regular approach
Outcomes
PICO 20.2
Population
Adults with fibromyalgia
Intervention
Resistence or strength exercise
Comparator
usual care
Outcomes
PICO 20.2
Population
Adults with chronic pain
Intervention
Acceptance and commitment therapy
Comparator
usual care or waiting list
Outcomes
PICO 20.2
Population
Adults with chronic pain
Intervention
Mindfulness
Comparator
cognitive behavioural therapy
Outcomes
PICO 20.2
Population
Selective serotonin reuptake inhibitors for fibromyalgia syndrome
Intervention
SSRI - Paroxetine
Comparator
placebo
Outcomes
PICO 20.2
Population
Low back pain
Intervention
Tramadol (Opioid)
Comparator
Flupirtine (non-opioid)
Outcomes
PICO 20.2
Population
Chronic low back pain
Intervention
Strong opioids (hydromorphone, buprenorphine, oxycodone, fentanyl, metadone)
Comparator
Placebo
Outcomes
PICO 20.3
Population
Adults with fibromyalgia
Intervention
Stretching
Comparator
Usual care
Outcomes
PICO 20.3
Population
Adults with chronic pain
Intervention
Positive psychology interventions
Comparator
Usual care
Outcomes
PICO 20.3
Population
Adults with fibromyalgia
Intervention
Mindfulness
Comparator
Usual care
Outcomes
PICO 20.3
Population
Fibromyalgia - Chronic Primary Pain
Intervention
SSRI - Fluoxetine
Comparator
placebo
Outcomes
PICO 20.3
Population
Chronic musculoskeletal pain (OA or LBP)
Intervention
Tapentadol Extended Release
Comparator
Placebo
Outcomes
PICO 20.4
Population
Adults with fibromyalgia
Intervention
Sensorimotor training
Comparator
Usual care
Outcomes
PICO 20.4
Population
Adults with fibromyalgia
Intervention
Cognitive behavioural therapy
Comparator
usual care or waiting list
Outcomes
PICO 20.4
Population
Women with fibromyalgia
Intervention
Mindfulness
Comparator
Usual care
Outcomes
PICO 20.4
Population
Fibromyalgia - Chronic Primary Pain
Intervention
SSRI - Citalopram
Comparator
placebo
Outcomes
PICO 20.4
Population
Chronic noncancer pain
Intervention
Any opioid
Comparator
Non-opioid
Outcomes
PICO 20.5
Population
Adults with fibromyalgia
Intervention
Mixed exercise training protocols that include two or more types of exercise (aerobic, resistance, flexibility)
Comparator
Control (treatment as usual, wait list control), non exercise (e.g. biofeedback), or other exercise (e.g. mixed versus flexibility) interventions
Outcomes
PICO 20.5
Population
Women with fibromyalgia
Intervention
Cognitive behavioral therapy
Comparator
Usual care
Outcomes
PICO 20.5
Population
Patiënten met fibromyalgia
Intervention
Mindfulness
Comparator
usual care
Outcomes
PICO 20.5
Population
Chronic pain (different types)
Intervention
Opioids
Comparator
Other opioids
Outcomes
PICO 20.6
Population
Adults with fibromyalgia
Intervention
Aerobic exercise
Comparator
Usual care
Outcomes
PICO 20.6
Population
Patiënten met fibromyalgia
Intervention
Psychological therapies
Comparator
usual care
Outcomes
PICO 20.6
Population
Adults with CLBP
Intervention
Mindfulness
Comparator
Usual care
Outcomes
PICO 20.7
Population
Women with fibromyalgia
Intervention
Acceptance and commitment therapy
Comparator
Usual care
Outcomes
PICO 20.8
Population
Adults with chronic low back pain
Intervention
Cognitive behavioural therapy
Comparator
Usual care
Outcomes
PICO 30.1
Population
Fibromyalgia
Intervention
Amitriptyline (25-50 mg daily)
Comparator
Placebo
Outcomes
PICO 30.1
Population
Chronic low back pain or osteoarthritis
Intervention
Duloxetine
Comparator
Placebo
Outcomes
PICO 30.1
Population
CNCP (KOA and LBP)
Intervention
Tapentadol extended release
Comparator
Placebo
Outcomes
PICO 30.1
Population
Opioids
Intervention
Comparator
Outcomes
PICO 30.2
Population
Any chronic pain (secondary and primary, ex headache)
Intervention
Any AD
Comparator
Placebo
Outcomes
PICO 30.2
Population
CNCP (OA and LBP)
Intervention
Opioid analgesic (3 steps)
Comparator
Non opioid analgesic (3 steps)
Outcomes
PICO 30.3
Population
Mixed (LBP, RA, arm pain from repetitive use)
Intervention
Amitriptyline (TCA)
Comparator
Other intervention/placebo
Outcomes
PICO 30.3
Population
CNCP
Intervention
Opioid
Comparator
Other opioid
Outcomes
PICO 40.1
Population
Patients with fibromyalgia
Intervention
Dietary supplements
Comparator
Outcomes
PICO 40.1
Population
Fibromyalgia
Intervention
Mirtazapine
Comparator
Placebo
Outcomes
PICO 40.2
Population
Adults, aged ≥18 years of age, if diagnosed with FMS by ACR criteria
Intervention
Dietary interventions
Comparator
Control
Outcomes
PICO 50.1
Population
Chronic pain (OA, LBP, osteoporosis, FM)
Intervention
Thai Chi
Comparator
Control
Outcomes
PICO 50.1
Population
Fibromyalgia - Chronic Primary Pain
Intervention
SNRIs (duloxetine, milnacipran) [If pooled]
Comparator
Placebo
Outcomes
PICO 50.1
Population
Pregabalin for fibromyalgia in adults
Intervention
Pregabalin
Comparator
placebo (studies of classic design)
Outcomes
PICO 50.2
Population
Fibromyalgia
Intervention
Tai Chi
Comparator
Standard care
Outcomes
PICO 50.2
Population
Fibromyalgia - Chronic pain
Intervention
Combination therapy
Comparator
Any other intervention
Outcomes
PICO 50.2
Population
Fibromyalgia - Chronic Primary Pain
Intervention
Antieileptics different doses
Comparator
Active comparator - Placebo
Outcomes
PICO 50.3
Population
Arthritis
Intervention
Tai Chi
Comparator
No intervention (incl. usual care and minimal care)
Outcomes
PICO 50.3
Population
Gabapentin for fibromyalgia in adults
Intervention
Gabapentin
Comparator
Placebo or any other active comparator
Outcomes
PICO 50.4
Population
Low back pain
Intervention
Tai Chi
Comparator
No intervention (incl. usual care and minimal care)
Outcomes
PICO 50.4
Population
Adults with fibromyalgia
Intervention
Pregabalin and duloxetin
Comparator
Placebo or individual drugs
Outcomes
PICO 50.5
Population
Chronic pain of any origin
Intervention
Qigong (external or internal)
Comparator
Waiting list/placebo/general care
Outcomes
PICO 50.6
Population
Yoga for chronic non-specific low back pain
Intervention
Yoga
Comparator
non-exercise
Outcomes
PICO 50.7
Population
Yoga for chronic non-specific low back pain
Intervention
Yoga
Comparator
exercise
Outcomes
PICO 50.8
Population
Non-specific chronic neck pain
Intervention
Yoga
Comparator
Other therapies (Pilates/Exercise/Complementary and alternative medicines)
Outcomes
PICO 50.9
Population
People with chronic low back pain
Intervention
Pilates exercise
Comparator
Usual care and physical activity (unknown other treatments, no treatment, education, medications or consultations with health professionals), massage therapy and other forms of exercise (ranged from cycling, McKenzie exercise, traditional lumbar stabilisation exercise, and a mixed form of exercise including stretching, strengthening and stabilisation)
Outcomes
PICO 50.10
Population
Adults with chronic pain
Intervention
Neurofeedback (any EEG or fMRI-based feedback training)
Comparator
Placebo
Outcomes
PICO 50.11
Population
Adults with fibromyalgia
Intervention
Biofeedback
Comparator
Usual care
Outcomes
PICO 50.12
Population
Patiënten met fibromyalgia
Intervention
Biofeedback
Comparator
usual care
Outcomes
PICO 50.13
Population
Adults with chronic back pain
Intervention
Biofeedback
Comparator
Various different control groups
Outcomes
PICO 50.14
Population
Individuals with any type of chronic pain
Intervention
EEG neurofeedback
Comparator
Control/other treatments
Outcomes
PICO 50.15
Population
Adults with chronic pain
Intervention
Autogenic training
Comparator
Usual care
Outcomes
PICO 50.16
Population
Chronic fatigue syndrome or fibromyalgia.
Intervention
Relaxation therapy (stand-alon therapy)
Comparator
Any control
Outcomes
PICO 50.17
Population
Patiënten met fibromyalgia
Intervention
Relaxation
Comparator
usual care
Outcomes
PICO 50.18
Population
Patients of any age with a clinical diagnosis of FM
Intervention
Guided imagery/hypnosis (GI/H)
Comparator
Control
Outcomes
PICO 50.19
Population
Adults with chronic musculoskeletal and neuropathic pain
Intervention
Hypnosis and/or self-hypnosis treatment
Comparator
Control
Outcomes
PICO 50.20
Population
Adults with chronic pain
Intervention
Manual therapy
Comparator
Usual care
Outcomes
PICO 50.21
Population
People with musculoskeletal disorders
Intervention
Massage therapy (manual manipulation of the soft tissues) as a stand-alone intervention
Comparator
The comparison therapy could not be an alternative form of massage
Outcomes
PICO 50.22
Population
Chronic non-cancer pain patients 18 years or older
Intervention
Osteopathic manual therapy as an active or combination intervention
Comparator
Control or comparison group
Outcomes
PICO 50.23
Population
Adults with fibromyalgia
Intervention
Manual therapy
Comparator
Usual care
Outcomes
PICO 50.24
Population
Patients confirmed with the diagnosis of FM
Intervention
Manual therapy
Comparator
Sham treatment, no treatment (control), active therapies (e.g., exercise) or other physiotherapy interventions
Outcomes
PICO 50.25
Population
Adults with chronic and nonspecific low back pain
Intervention
Mobilization or manipulation therapies
Comparator
Other active therapies, such as exercise, physiotherapy, or physical therapy
Outcomes
PICO 50.26
Population
Patients with chronic nonspecific neck pain;
Intervention
Mobilization and/or manipulation therapies
Comparator
Sham, no treatment, each other, and other active therapies, or when combined as multimodal therapeutic approaches
Outcomes
PICO 50.27
Population
Adults with CNP
Intervention
Manual therapy
Comparator
Usual care
Outcomes
PICO 50.28
Population
Adults with grade I-II neck pain
Intervention
Combination of manual therapy (MT) and exercise therapy (ET)
Comparator
Manual therapy (MT) or exercise therapy (ET) alone
Outcomes
PICO 50.29
Population
Individuals with chronic pain
Intervention
Traditional Thai massage (TTM)
Comparator
Control group
Outcomes
PICO 50.30
Population
Adults with fibromyalgia
Intervention
Balneotherapy
Comparator
Usual care
Outcomes
PICO 50.31
Population
Adults with chronic and acute pain
Intervention
TENS
Comparator
Placebo/sham
Outcomes
PICO 50.32
Population
Adults with chronic and acute pain
Intervention
TENS
Comparator
Usual care
Outcomes
PICO 50.33
Population
Adults with fibromyalgia
Intervention
TENS alone or added to usual care (including exercise)
Comparator
Placebo (sham) TENS; no treatment; exercise alone; or other treatment including medication, electroacupuncture, warmth therapy, or hydrotherapy
Outcomes
PICO 50.34
Population
Adults with chronic back pain
Intervention
TENS
Comparator
Control
Outcomes
PICO 50.35
Population
Adults with chronic neck pain
Intervention
TENS
Comparator
Sham
Outcomes
PICO 50.36
Population
Adults with chronic non-specific low back pain
Intervention
Low-level laser treatment (including laser acupuncture)
Comparator
Sham controls and blinded assessment
Outcomes
PICO 50.37
Population
Myofascial pain
Intervention
Various electric stimulation techniques
Comparator
Control
Outcomes
PICO 50.38
Population
Patients with FM
Intervention
Invasive or non-invasive electric stimulation (ES)
Comparator
Control group (no electric current transmission)
Outcomes
PICO 50.39
Population
Adults with chronic musculoskeletal pain
Intervention
Myofascial release therapy excluding myofascial trigger point treatment, non-specific massage, or other types of manual therapy
Comparator
Any other treatment, placebo, sham, or no treatment
Outcomes
PICO 50.40
Population
Adults (+18 years) with medical diagnosis of fibromyalgia
Intervention
Myofascial release
Comparator
Placebo, usual care, active treatment or waiting list
Outcomes
PICO 50.41
Population
Patients (+18) diagnosed with fibromyalgia syndrome using American College of Rheumatology Criteria
Intervention
Myofascial release alone or in combination with exercise
Comparator
Sham treatment, placebo treatment (inactive treatment without actual physiological effect), no treatment, or active treatment (a treatment directed to the condition) in the form of exercise or any other physiotherapy treatment
Outcomes
PICO 50.42
Population
Individuals with chronic mechanical neck pain
Intervention
Myofascial release
Comparator
Conventional intervention
Outcomes
PICO 50.43
Population
Patients with chronic low back pain
Intervention
Myofascial release
Comparator
Sham, exercices, spinal manipulatuion or physiotherapy
Outcomes
PICO 50.44
Population
Adult patients with a chronic, non-malignant pain condition of any cause, duration, or intensity
Intervention
Craniosacral therapy regardless of length or content
Comparator
Active or inactive comparators such as: treatment as usual, waiting list, sham, pharmacological therapies, or non-pharmacological comparators
Outcomes
PICO 50.45
Population
Adults aged 18 – 70 years old with chronic pain conditions
Intervention
Music intervention
Comparator
Control
Outcomes
PICO 50.46
Population
Patients with fibromyalgia
Intervention
Music therapy
Comparator
Control
Outcomes
PICO 50.47
Population
Acupuncture for chronic nonspecific low back pain
Intervention
Acupuncture
Comparator
sham intervention
Outcomes
PICO 50.48
Population
Acupuncture for chronic nonspecific low back pain
Intervention
Acupuncture
Comparator
no treatment
Outcomes
PICO 50.49
Population
Acupuncture for chronic nonspecific low back pain
Intervention
Acupuncture
Comparator
usual care
Outcomes
PICO 50.50
Population
Adults with chronic back pain (cervical, dorsal and lumbal)
Intervention
Auricular acupuncture or acupressure
Comparator
Sham, waiting list, standard medical treatment/active treatment or no treatment
Outcomes
PICO 50.51
Population
Fibromyalgia
Intervention
Acupuncture
Comparator
Control
Outcomes
PICO 50.52
Population
Fibromyalgia
Intervention
Dry needling
Comparator
Control
Outcomes
PICO 50.53
Population
Adults with chronic back pain
Intervention
Cupping therapy
Comparator
Sham, active treatment, waiting list, standard medical treatment or no treatment
Outcomes